Effects of physical stimulation on diffuse noxious inhibitory controls (DNIC) in pain control mechanisms

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The aim of this study was to clarify the diffuse pain inhibitory effects of physical stimulation. Physical stimulation e.g. pressure, electrical, vibratory and thermal stimulation could decrease the pain sensitivities on distal region from stimulation point and change pain-related parameter such as heart rate variability in healthy volunteer, whereas these effects were limited on local part stimulated in chronic pain subjects. These findings suggest: (i) that not only painful but also non-painful physical stimulation can have the diffuse pain inhibitory effects via supraspinal descending analgesia system and (ii) that the pain control mechanism may be disturbed in chronic pain subjects.