A new predicting method and health guidance for the progression of subclinical atherosclerosis using new lifestyle-related serum markers.

使用新的生活方式相关血清标志物来预测亚临床动脉粥样硬化进展的新方法和健康指导。

• 批准号: 22500663
• 负责人: NISHIDA Makoto
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500663/
• 关键词: 動脈硬化; 危険因子; 生活習慣; 酸化ストレス; アポ蛋白; 特定健診; タバコ

New serum markers which may indicate carotid atherosclerosis were evaluated with life-style in annual health checkup. ApoB48, a marker for lipids absorbed from intestine, did not correlate with atherosclerosis in all subjects, but significantly correlated in non-obese subjects. It shows apoB48 can be an useful marker detecting atherosclerosis in non-obese subjects. Other new markers including oxidative stress did not associate with progression of atherosclerosis, but with risk factors. Notably, smoking significantly associated progression of atherosclerosis even in a short period. It emphasizes the importance to stop smoking early.

在每年的健康体检中，根据生活方式对可能提示颈动脉粥样硬化的新的血清标志物进行评估。ApoB48是从肠道吸收脂肪的标志，在所有受试者中与动脉粥样硬化无关，但在非肥胖者中显著相关。提示apoB48可作为检测非肥胖者动脉粥样硬化的有用标志物。包括氧化应激在内的其他新标记物与动脉粥样硬化的进展无关，但与风险因素有关。值得注意的是，吸烟与动脉粥样硬化的进展显著相关，即使在很短的时间内也是如此。它强调了及早戒烟的重要性。

项目成果

Prevention of Subclinical Atherosclerosis : Search for Gender-specific Risk Factors and Salutary Interventions Against its Progression

亚临床动脉粥样硬化的预防：寻找性别特异性危险因素和针对其进展的有益干预措施

• 发表时间: 2012
• 作者: Shoji Sanada;Makoto Nishida;et al
• 通讯作者: et al

Smoking Promotes Subclinical Atherosclerosis in Apparently Healthy Men

吸烟会促进表面健康男性的亚临床动脉粥样硬化

• DOI: 10.1253/circj.cj-11-1506
• 发表时间: 2012
• 期刊: Circulation Journal
• 影响因子: 3.3
• 作者: Sanada S;Nishida M;他4名
• 通讯作者: 他4名

Oxidative Stress Predicts Worsening of Metabolic Risk Factors Independent of Adiposity

氧化应激预测与肥胖无关的代谢风险因素恶化

• 发表时间: 2011
• 作者: Makoto Nishida;et al;西田誠 他;西田誠 他
• 通讯作者: 西田誠 他

Serum Apolipoprotein B-48 Level Is Associated with Subclinical Athero- sclerosis in Non-obese Men

血清载脂蛋白 B-48 水平与非肥胖男性的亚临床动脉粥样硬化有关

• 发表时间: 2011
• 作者: Makoto Nishida;et al.
• 通讯作者: et al.

Serum Apolipoprotein B-48 Level, But Not Remnant-like Particle Cholesterol Level, is Associated with Subclinical Atherosclerosis in Non-obese Men

血清载脂蛋白 B-48 水平（而非残留样颗粒胆固醇水平）与非肥胖男性的亚临床动脉粥样硬化相关

• 发表时间: 2011
• 作者: Makoto Nishida;et al;西田誠 他
• 通讯作者: 西田誠 他