The study of the development of anti-cancer drug which targets human septin 4 (Bradeion) GTPase

我们的研究成功地提供了一种实用的工具(血清检测)来诊断早期癌症，如良性息肉和腺瘤，并通过结肠镜对这些病变进行解剖，从而在候选人群中进行癌症预防。系统地寻找一种新的抗癌候选药物在体外对癌细胞的毒性大于疗效，我们不得不得出结论，已知的候选药物都不能应用于临床。然而，我们同时搜索并发现了一种中国化合物，凯基，它已经被介绍给日本有宅NCI医院的患者。有限数量的结果显示，通过激活细胞免疫和抑制肿瘤血管生成，对肝癌和其他腺癌有显著的控制作用。我们正在将凯基应用到果蝇系统中，以展示其对癌细胞中蛋白质-蛋白质和遗传系统的详细效果。

Our research succeeded to provide a practical tool (serum test) to diagnose early stage of cancer such as benign polyps and adenoma, and colonoscopic dissection of these lesions consequently leads to cancer prevention in candidate population. Systematic search for a novel anti-caner drug candidates resulted in more toxicity than efficacy on cancer cells in vitro, and we had to conclude that none of the known candidates could apply in clinics. However, we simultaneously searched and discovered a Chinese compound, Kaiji, which has been introduced to the patients in the NCI Hospital, Ariake, Japan. The limited number of the results showed significant controlling effect on hepatoma and the other adenocarcinoma, by activation of cellular immunity and also by the inhibition of angiogenesis in tumor. We are now applying Kaiji to Drosophila system to show the detailed efficacy on protein-protein and genetic system in cancer cells.