Why have nematode a radiation tolerance? :Elucidation of the resistant mechanism.

众所周知，线虫具有很强的辐射耐受性。线虫幼虫对恶劣的环境条件作出反应，通过环境改造，线虫幼虫经历达日尔期，恢复正常阶段。中等剂量的X射线照射延长了达尔幼虫的寿命。我们发现，与代谢调节/应激反应相关的一些代谢调节/抗氧化酶的基因表达在X射线照射后的达尔幼虫中上调。特别是转录因子MXL-3在辐射耐受中的作用。

It is known that nematode shows strong radiation tolerance. In response to harsh environmental conditions, nematode C. elegans larvae undergo dauer stage and recover the normal stage by environmental reform. Modest doses X-irradiation of dauer larvae increased their post-dauer longevity. We founded that the gene expressions of some enzymes of metabolic regulation/anti-oxidation related with metabolic regulation/stress response were up-regulated in the X-ray irradiated dauer larvae. Especially, it is suggested that a transcription factor, mxl-3 plays a role of radiation tolerance