Reaction Mechanism of new vitamin E analog for protecting radiation injuries

新型维生素E类似物防护辐射损伤的反应机制

• 批准号: 22510066
• 负责人: ANZAI Kazunori
• 金额: $ 2.83万
• 依托单位: Nihon Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22510066/
• 关键词: 放射線防護剤; ビタミンE誘導体; 骨髄死; 血球系細胞; サイトカイン; 経口投与; 皮下投与; 放射線かん治療; 放射線防御

Several vitamin E analogs were examined against radiation-induced bone marrow death of mice and γ-tocopherol dimethylglycine ester was found to be most effective. It increased the survival of mice after whole body exposure of X-rays or carbon heavy atom radiation. The effect was found to be derived from the increase of the recovery of hematopoietic cells. The compound did not inhibit the control of tumor growth by local carbon heavy atom radiation using mouse xenograft model.

研究了几种维生素E类似物对辐射诱导的小鼠骨髓死亡的影响，发现γ-生育酚二甲基甘氨酸酯最有效。它增加了全身暴露在x射线或碳重原子辐射下的小鼠的存活率。这种效果是由于造血细胞恢复的增加而产生的。该化合物不抑制局部碳重原子辐射对小鼠异种移植瘤模型肿瘤生长的控制。

项目成果

密度汎関数計算に基づく新規ビタミンE誘導体の分子設計とラジカル消去活性評価

基于密度泛函计算的新型维生素E衍生物的分子设计和自由基清除活性评价

• 发表时间: 2010
• 作者: 中西郁夫;ら
• 通讯作者: ら

Gamma-tocopherol-N,N-dimethylglycine ester as a potent post-irradiation mitigator against total body X-irradiation-induced bone marrow death in mice

γ-生育酚-N,N-二甲基甘氨酸酯作为有效的辐射后缓解剂，对抗全身 X 射线辐射引起的小鼠骨髓死亡

• 期刊: J. Radiat. Res
• 作者: Kazunori Anzai;Megumi Ueno;Ken-ichiro Matsumoto;Nobuo Ikota;Jiro Takata
• 通讯作者: Jiro Takata

Radiation mitigators : Compounds, which are effective when administered immediately after exposure to radiations

辐射缓和剂：在暴露于辐射后立即施用时有效的化合物

• 发表时间: 2011
• 作者: Kazunori Anzai;Megumi Ueno;Ken-ichiro Matsumoto;Jiro Takata
• 通讯作者: Jiro Takata

Nuclear Power Plant accident: facts, environmental contamination, possible biological effects, and countermeasures

核电站事故：事实、环境污染、可能的生物效应和对策

• 发表时间: 2012
• 期刊: J. Clin. Biochem. Nutr
• 作者: Kazunori Anzai;Nobuhiko Ban;Toshihiko Ozawa;Shinji Tokonami;Fukushima Daiichi
• 通讯作者: Fukushima Daiichi

Vitamin E-deficiency did not exacerbate patial skin reactions in mice locally irradiated with X-rays

维生素 E 缺乏不会加剧接受 X 射线局部照射的小鼠的局部皮肤反应

• 发表时间: 2011
• 期刊: Journal of Radiation Research
• 影响因子: 2
• 作者: Cuiping Chi;Daisuke Hayashi;Masato Nemoto;Minako Nyui;Shiro Urano;Kazunori Anzai
• 通讯作者: Kazunori Anzai