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Reaction Mechanism of new vitamin E analog for protecting radiation injuries

Reaction Mechanism of new vitamin E analog for protecting radiation injuries
新型维生素E类似物防护辐射损伤的反应机制
批准号:
22510066
负责人:
ANZAI Kazunori
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Several vitamin E analogs were examined against radiation-induced bone marrow death of mice and γ-tocopherol dimethylglycine ester was found to be most effective. It increased the survival of mice after whole body exposure of X-rays or carbon heavy atom radiation. The effect was found to be derived from the increase of the recovery of hematopoietic cells. The compound did not inhibit the control of tumor growth by local carbon heavy atom radiation using mouse xenograft model.
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会议论文
密度汎関数計算に基づく新規ビタミンE誘導体の分子設計とラジカル消去活性評価
基于密度泛函计算的新型维生素E衍生物的分子设计和自由基清除活性评价
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [中西郁夫, ら]
通讯作者:
Gamma-tocopherol-N,N-dimethylglycine ester as a potent post-irradiation mitigator against total body X-irradiation-induced bone marrow death in mice
γ-生育酚-N,N-二甲基甘氨酸酯作为有效的辐射后缓解剂,对抗全身 X 射线辐射引起的小鼠骨髓死亡
DOI: --
发表时间:
期刊: J. Radiat. Res
影响因子: --
作者: [Kazunori Anzai, Megumi Ueno, Ken-ichiro Matsumoto, Nobuo Ikota, Jiro Takata]
通讯作者: Jiro Takata
Radiation mitigators : Compounds, which are effective when administered immediately after exposure to radiations
辐射缓和剂:在暴露于辐射后立即施用时有效的化合物
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kazunori Anzai, Megumi Ueno, Ken-ichiro Matsumoto, Jiro Takata]
通讯作者: Jiro Takata
DOI: --
发表时间: 2012
期刊: J. Clin. Biochem. Nutr
影响因子: --
作者: [Kazunori Anzai, Nobuhiko Ban, Toshihiko Ozawa, Shinji Tokonami, Fukushima Daiichi]
通讯作者: Fukushima Daiichi
24
    Establishnent of In vivo ESR Imaging System for Oxidativte Stress in Brain
    Phospholipid translocation in various bilayr membranes using radioactive phospholipid probes
    • 批准号:
      05671784
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.34万
    • 财政年份:
      1993
    • 负责人:
      ANZAI Kazunori
    • 依托单位:
    Synthetic Model Peptides for the Study of Structure-Activity Relationship of Ion Channels Using Planar Lipid Bilayer Technique
    • 批准号:
      03671027
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.34万
    • 财政年份:
      1991
    • 负责人:
      ANZAI Kazunori
    • 依托单位:
    海外基金