Searching for the causative genes and susceptibility SNPs for diabetes mellitus based on the linkage analysis data

对于2型糖尿病易感基因，我们在21号染色体上发现了两个基因，LSS和KCNJ15，位于我们报道的LOD曲线的峰值之下。我们发现，通过在糖尿病动物中施用siRNA抑制每个基因的表达，葡萄糖水平得到改善，表明LSS和KCNJ15可以作为2型糖尿病的治疗靶点。我们还利用新一代测序仪在一个MODY大家族中发现了两个致病基因

For type 2 diabetes susceptibility genes, we have identified two genes, LSS and KCNJ15 on chromosome 21, under the peak of LOD curve we had reported. We showed that glucose levels were improved by suppressing the expression of each gene by administration of siRNA in diabetic animal, indicating that LSS and KCNJ15 could be the therapeutic targets for type 2 diabetes. We also found two causative genes by using next generation sequencers in a large MODY family