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Excited state of substituted nucleic-acid bases and their oxygen complexes for photodynamic therapy

Excited state of substituted nucleic-acid bases and their oxygen complexes for photodynamic therapy
用于光动力治疗的取代核酸碱基及其氧复合物的激发态
批准号：
22550007
负责人：
SUZUKI Tadashi
金额：
$3.0万
依托单位：
Aoyama Gakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22550007/
关键词：
核酸塩基励起状態一重項酸素緩和過程光線力学療法近赤外発光過渡吸収光音響法酸素錯体

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英文摘要
Excited state and relaxation/reaction processes of S- or N-substituted nucleic-acid bases have been studied by transient absorption spectroscopy, photothermal spectroscopy, near-infrared spectroscopy, and quantum chemical calculations. The quantum yield of the substituted bases was almost unity; however, it strongly depended on the character of the excited singlet state. Non-resonant two-photon absorption spectrum by optical-probing photoacoustic spectroscopy, singlet oxygen formation and its reaction were also discussed. These distinct properties clearly indicate that the substituted bases have a high potential for photodynamic therapy.
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Excited State Properties of Thio- and Aza-Substituted Nucleoacids/Nucleosides and Their PDT Applications
硫代和氮杂取代的核酸/核苷的激发态性质及其PDT应用
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Y. Kumagai, T. Odagiri, T. Tanabe, M.Nakano, I. H Suzuki, N. Kouchi, T. Suzuki and T. Isozaki]
通讯作者： T. Suzuki and T. Isozaki
Multi-photon Excitation Studies of Thioganosine as a Potential Agent for Photodynamic Therapy
硫甘苷作为光动力治疗潜在药物的多光子激发研究
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [Tasuku Isozaki, Jun Ikemi, Tadashi Suzuki]
通讯作者： Tadashi Suzuki
Effect of Basic Amino Acids on Photoreaction of Ketoprofen in Phosphate Buffer Solution
DOI： 10.1111/j.1751-1097.2012.01132.x
发表时间： 2012-07
期刊： Photochemistry and Photobiology
影响因子： 3.3
作者： [Tadashi Suzuki;Yohei Osanai;T. Isozaki]
通讯作者： Tadashi Suzuki;Yohei Osanai;T. Isozaki
光検山光音響法を用いたチオ置換核酸塩基の二光子吸収スペクトル
使用光学检测光声方法测定硫代核碱基的双光子吸收光谱
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [池見淳, 磯崎輔, 鈴木正]
通讯作者： 鈴木正
共 19 条
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    • 批准号：
      19510239
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $1.41万
    • 财政年份：
      2007
    • 负责人：
      SUZUKI Tadashi
    • 依托单位：
      Tokyo Metropolitan University
    The Basic Study for the Construction of Political and Social Data Base of the Middle Eastern Core Area
    • 批准号：
      17300079
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.47万
    • 财政年份：
      2005
    • 负责人：
      SUZUKI Tadashi
    • 依托单位：
      The University of Tokyo
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