Excited state of substituted nucleic-acid bases and their oxygen complexes for photodynamic therapy

用于光动力治疗的取代核酸碱基及其氧复合物的激发态

• 批准号: 22550007
• 负责人: SUZUKI Tadashi
• 金额: $ 3万
• 依托单位: Aoyama Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22550007/
• 关键词: 核酸塩基; 励起状態; 一重項酸素; 緩和過程; 光線力学療法; 近赤外発光; 過渡吸収; 光音響法; 酸素錯体

Excited state and relaxation/reaction processes of S- or N-substituted nucleic-acid bases have been studied by transient absorption spectroscopy, photothermal spectroscopy, near-infrared spectroscopy, and quantum chemical calculations. The quantum yield of the substituted bases was almost unity; however, it strongly depended on the character of the excited singlet state. Non-resonant two-photon absorption spectrum by optical-probing photoacoustic spectroscopy, singlet oxygen formation and its reaction were also discussed. These distinct properties clearly indicate that the substituted bases have a high potential for photodynamic therapy.

用暂态吸收光谱、光热光谱、近红外光谱和量子化学计算研究了S或N-取代核酸碱基的激发态和驰豫/反应过程。取代碱的量子产额几乎为1，但它强烈依赖于激发单重态的性质。还讨论了光学探测光声光谱的非共振双光子吸收光谱、单线态氧的形成及其反应。这些独特的性质清楚地表明，取代碱在光动力疗法中具有很高的潜力。

项目成果

Excited State Properties of Thio- and Aza-Substituted Nucleoacids/Nucleosides and Their PDT Applications

硫代和氮杂取代的核酸/核苷的激发态性质及其PDT应用

• 发表时间: 2011
• 作者: Y. Kumagai;T. Odagiri;T. Tanabe;M.Nakano;I. H Suzuki;N. Kouchi;T. Suzuki and T. Isozaki
• 通讯作者: T. Suzuki and T. Isozaki

Multi-photon Excitation Studies of Thioganosine as a Potential Agent for Photodynamic Therapy

硫甘苷作为光动力治疗潜在药物的多光子激发研究

• 发表时间: 2012
• 作者: Tasuku Isozaki;Jun Ikemi;Tadashi Suzuki
• 通讯作者: Tadashi Suzuki

Effect of Basic Amino Acids on Photoreaction of Ketoprofen in Phosphate Buffer Solution

• DOI: 10.1111/j.1751-1097.2012.01132.x
• 发表时间: 2012-07
• 期刊: Photochemistry and Photobiology
• 影响因子: 3.3
• 作者: Tadashi Suzuki;Yohei Osanai;T. Isozaki

チオ置換核酸塩基のPDTへの応用とチオールの影響

硫代核碱基在PDT中的应用及硫醇的影响

• 发表时间: 2011
• 作者: Y.Yoshioka;M.Mitani;Kazuma Gotohand Hiroyuki Ishida;鈴木正・宮下恵・磯崎輔
• 通讯作者: 鈴木正・宮下恵・磯崎輔

光検山光音響法を用いたチオ置換核酸塩基の二光子吸収スペクトル

使用光学检测光声方法测定硫代核碱基的双光子吸收光谱

• 发表时间: 2011
• 作者: 池見淳;磯崎輔;鈴木正
• 通讯作者: 鈴木正