Structure and functional analysis of the GCase receptor by x-ray

ANP受体是关酰环化酶（GCase）受体家族的一员，在调节人体血压和体液平衡中起关键作用。“GCase受体如何识别激素”和“受体如何将激素结合信号传递到其细胞内区域”的机制仍然未知。为了阐明其机制，我们对ANP受体的细胞外配体结构域进行了x射线晶体学研究，并对受体进行了动力学实验。

ANP receptor, which belongs to a member of guanylyl cyclase (GCase) receptor family,plays a key role in the regulation of blood pressure and body fluid balance in our body.The mechanisms "how the GCase receptor recognizes hormone" and "how the receptortransmits the hormone-binding signal to its intracellular domain” are still unknown.To elucidate the mechanisms, we performed x-ray crystallography of the ANP receptorextracellular domain complexed with ligands and kinetics experiments of the receptor.