Structure and functional analysis of the GCase receptor by x-ray

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ANP receptor, which belongs to a member of guanylyl cyclase (GCase) receptor family,plays a key role in the regulation of blood pressure and body fluid balance in our body.The mechanisms "how the GCase receptor recognizes hormone" and "how the receptortransmits the hormone-binding signal to its intracellular domain” are still unknown.To elucidate the mechanisms, we performed x-ray crystallography of the ANP receptorextracellular domain complexed with ligands and kinetics experiments of the receptor.