Exploration of novel anthelmintics from rare sugars and their ester derivatives

研究了稀有糖及其酯类化合物对秀丽线虫的驱虫活性。在醛已糖立体异构体中，D-异构体是D-葡萄糖的C3异构体，对线虫的生长有抑制作用。我们发现D-异构体的脂肪酸酯的驱虫活性超过了糖本身。6-O-辛酰基-D-异构体在D-异构体脂肪酸酯中毒性最强。

Rare sugars and their ester derivatives were examined for anthelmintic activity against the nematode Caenorhabditis elegans. Among the aldohexose stereoisomers, D-allose, the C3 epimer of D-glucose, inhibited the growth of C. elegans. We found that fatty acid estersof D-allose surpassed the sugar itself in anthelmintic activity. 6-O-octanoyl-D-allose showed the strongest toxicity among the fatty acid esters of D-allose.