Exploration of novel anthelmintics from rare sugars and their ester derivatives

研究了稀有糖及其酯衍生物对秀丽隐杆线虫的驱虫活性。醛己糖立体异构体中，d -葡萄糖的C3外显体d -醛己糖抑制线虫的生长。我们发现脂肪酸酯D-allose的驱虫活性超过糖本身。6- o -辛烷酰- d -醛脲在d -醛脲的脂肪酸酯中毒性最强。

Rare sugars and their ester derivatives were examined for anthelmintic activity against the nematode Caenorhabditis elegans. Among the aldohexose stereoisomers, D-allose, the C3 epimer of D-glucose, inhibited the growth of C. elegans. We found that fatty acid estersof D-allose surpassed the sugar itself in anthelmintic activity. 6-O-octanoyl-D-allose showed the strongest toxicity among the fatty acid esters of D-allose.