Mechanism of inhibitory activityof lipolysis by basic polypeptide.

我们发现碱性生物聚合物如碱性多肽是胰脂肪酶反应的强抑制剂。它们可能与底物表面相互作用，抑制脂肪分解，并通过抑制肠道对膳食脂肪的吸收而具有抗肥胖功能。当碱性氨基酸聚合度达到10时，脂肪酶的抑制作用增强。碱性多肽可能是强的脂肪酶抑制剂，无副作用。因此，它们可以被认为是预防肥胖的潜在新工具。

We discovered that the basic biopolymers such as basic polypeptide was strong inhibitors of pancreatic lipase reaction. They might interact with substrate surface and inhibit lipolysis and have anti-obesity function that act by inhibiting intestinal absorption of dietary fat. The lipase inhibition increased with the degree of polymerization of basic amino acids up to 10. The basic polypeptide might be strong lipase inhibitors and free from side effect. Therefore, they could be considered a potential new tool to prevent obesity.