Global study using fluorescent Neospora caninum on the vertical transmission mechanism in neosporosis

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At first we visualized Neospora caninum by making a fluorescent color development this protozoan and facilitated various kinds of experiments of neosporosis in this study. We identified the gene encoded the NcBAG1 protein which could become the marker of bradyzoite stage. Furthermore, we confirmed the effect of this protein in the horizontal transmitted mouse model of the antigen derived from bradyzoite. The mixed vaccine of the both antigens showed synergy effects against the horizontal transmission, but the effect was not found in the vertical transmission. We were not able to confirm the effect of the estrogen in the vertical transmission in this study.