Molecular and morphological studies on roles of autophagy in tick starvation periods and their transmission of protozoan parasites.

关于自噬在蜱饥饿期间的作用及其原生动物寄生虫传播的分子和形态学研究。

• 批准号: 22580356
• 负责人: MATSUO Tomohide
• 金额: $ 2.91万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22580356/
• 关键词: マダニ媒介性疾病; フタトゲチマダニ; ピロプラズマ; 生存戦略; 節足動物; 原虫病; マダニ; 飢餓耐性; ベクター; 寄生虫; 原虫媒介

Ticks can feed a blood meal from most vertebrates except for fish and ingest a large amount of blood from hosts. Additionally, they seem to have a unique strategy to endure the off-host state for a long period. Autophagy is induced by starvation condition and is essential for life-span extention, therefore we speculate that autophagy also occurs in ticks. Some autophagy-related genes were isolated in Haemaphysalis longicornis, the most dominant tick in Japanese pastures and vector of piroplasmosis among grazing cattle, and then they were expressed during their unfed and moulting periods. It showed that autophagy plays an important role in tick suvival during long starvation periods.

蜱可以从除鱼类以外的大多数脊椎动物中吸血，并从宿主那里摄取大量血液。此外，它们似乎有一种独特的策略来长期忍受非宿主状态。自噬是由饥饿条件诱导的，是延长生命所必需的，因此我们推测自噬也发生在蜱类中。从日本牧场最主要的蜱类和放牧牛梨形虫病的传播媒介长角血蜱中分离到了一些自噬相关基因，并在其未进食期和换羽期表达。表明自噬在蜱类长期饥饿存活中起重要作用。

项目成果

Parasiticidal activity of Haemaphysalis longicornis longicin against Toxoplasma gondii

长角血蜱素对弓形虫的杀寄生虫活性

• 发表时间: 2011
• 作者: Tanaka;T.;et al
• 通讯作者: et al

Yano: Reproduction in a Metastriata tick, Haemaphysalis longicornis

Yano：Metastriata 蜱（Haemaphysalis longicornis）的繁殖

• 发表时间: 2011
• 作者: Matsuo;T.;N. Okura;H. Kakuda and Y.
• 通讯作者: H. Kakuda and Y.

Parasiticidal activity of Haemaphysalislongicornislongicin against Toxoplasma gondii.

Haemaphysalislongicornislongicin 对弓形虫的杀寄生虫活性。

• 发表时间: 2011
• 作者: Tanaka T.;H. Maeda;T. Matsuo;D. Boldbattar;R. Umemiya-Shirafuji;A. Kume;H. Suzuki;X. Xuan;N. Tsuji and K. Fujisaki
• 通讯作者: N. Tsuji and K. Fujisaki

フタトゲチマダニロンギシンP4のトキソプラズマに及ぼす影響

长弓硬蜱P4对弓形虫的作用

• 发表时间: 2010
• 作者: 田仲哲也;他
• 通讯作者: 他

マダニのオートファジー関連遺伝子とその役割

蜱中自噬相关基因及其作用

• 发表时间: 2012
• 作者: 白藤(梅宮)梨可;ら
• 通讯作者: ら