Synthesis of Biaryl Type Natural Organic Molecules

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Many organic compounds which possess a biaryl skeleton were found from the nature, and some exhibit interesting biological activities. However, there have been a few methods for the synthesis of highly functionalized biaryl molecules. Recently, a palladium-mediated intramolecular coupling reaction has been recognized as the useful technique for the construction of such compounds. In this study, we developed the synthetic methods for biaryl-type molecules, and performed the total synthesis of several natural products.