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Synthetic Studies on Structurally Novel Antitumor Natural Products, Hederacines

Synthetic Studies on Structurally Novel Antitumor Natural Products, Hederacines
结构新颖的抗肿瘤天然产物常春藤素的合成研究
批准号：
22590020
负责人：
AOYAGI Sakae
金额：
$2.83万
依托单位：
Tokyo University of Pharmacy and Life Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590020/
关键词：
合成化学天然物合成化学天然物合成

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中文摘要
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英文摘要
Hederacines A and B, isolated from Glechoma hederaceae, have structurescontaining anuniqueaza-tricycles and show moderate levels of cytotoxicity. In this study, racemic syntheses of 9-epi-hederacine A and 9-epi-hederacine B were achieved via a potential common intermediateprecursor.
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Toward the racemic total synthesis of hederacines A and B: construction of an advanced tricyclic intermediate.
DOI： 10.1021/ol2004353
发表时间： 2011-04
期刊： Organic letters
影响因子： 5.2
作者： [M. Yamashita;Tetsuya Yamashita;S. Aoyagi]
通讯作者： M. Yamashita;Tetsuya Yamashita;S. Aoyagi
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