Identification and functional analysis of chondroitin sulfatesinvolved in sizing and development of eye

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We tried to identify chondroitin sulfates closely related sizing and morphogenesis of eye and analyze its function. Chondroitin-4-sulfate and chondoritin-6-sulfate and its proteoglycans were distributed in the retina throughout the developmental periods. Especially, decorin, one of the chondroitin sulfate proteoglycans, were present in abundance in the entire eyeball. Injecting anti-decorin antibody in vitreous cavity on embryonic day 5.5 (HH stage 28), the expansion of chick embryo eye was significantly suppressed. However, proliferation and cell proliferation of retical cells were occurred regardless ofthe suppression of eye expansion. The sclera was also thickened and inhibited eye expansion. These results indicated that decorin involved in the determination of retinal formation and eyeball volume and sizing through the regulation of the expansion of the vitreous body.