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Electrophysiological analysis of colonic ion secretion mechanism by TRP channels

Electrophysiological analysis of colonic ion secretion mechanism by TRP channels
TRP通道结肠离子分泌机制的电生理分析
批准号:
22590201
负责人:
SHIMIZU Takahiro
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Since spices such as wasabi are used as stomach medicines in Oriental medicine, they are suggested to regulate colonic functions. In the present study, we investigated the mechanism that aryl isothiocyanates (AITC), which are a main pungent component of wasabi, triggers Clsecretion in colonic mucosa isolated from mice and rats. As a result, we demonstrated that AITC caused Clsecretion via PGE2 production in colonic mucosa and that TRPA1 channel may not be a key molecule in the AITC-induced Clsecretion in the colon. This study proposes a novel mechanism of AITC action in the colon
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Nakajima T, Ashihara T, et al., 石原圭子, 清水貴浩,高橋祐太,藤井拓人,竹口紀晃,酒井秀紀]
通讯作者: 清水貴浩,高橋祐太,藤井拓人,竹口紀晃,酒井秀紀
TMEM16F is an outwardly-rectifying Cl^- channel with distinct Ca^<2+> dependency
TMEM16F 是一种具有明显 Ca^<2> 依赖性的外向整流 Cl^- 通道
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Shimizu T, Iehara T, Sato K, Fujii T, Sakai H, Okada Y]
通讯作者: Okada Y
マウス胃酸分泌細胞に発現するSLC26Cl-チャネルの電気生理学的性質.
小鼠胃酸分泌细胞中表达的 SLC26Cl 通道的电生理特性。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Tsuji-Wakisaka K, Ashihara T, et al., 藤田恭輔,清水貴浩,二谷章大,藤井拓人,竹口紀晃,酒井秀紀]
通讯作者: 藤田恭輔,清水貴浩,二谷章大,藤井拓人,竹口紀晃,酒井秀紀
TRPP3チャネルのアルカリ感受性.
TRPP3 通道的碱性敏感性。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ding WG, Toyoda F, Ueyama H, Matsuura H, Seiichi Era, 清水貴浩,樋口大河,藤井拓人,Bernd Nilius,酒井秀紀]
通讯作者: 清水貴浩,樋口大河,藤井拓人,Bernd Nilius,酒井秀紀
19
    Basic research for treatment of lower urinary tract dysfunction based on the brain mechanisms for stress-induced frequent urination
    • 批准号:
      20K07827
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2020
    • 负责人:
      SHIMIZU Takahiro
    • 依托单位:
    Brain mechanisms for stress-induced exacerbation of frequent urination
    • 批准号:
      17K09303
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2017
    • 负责人:
      SHIMIZU Takahiro
    • 依托单位:
    Basic research for exploitation of novel central antihypertensive drugs focusing on regulation of responses to stress
    • 批准号:
      26460909
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2014
    • 负责人:
      SHIMIZU Takahiro
    • 依托单位:
    Construction of a conceptual model representing interpersonal situation in a mental nursing scene:From response to acting out of patients with borderline personality disorder
    • 批准号:
      26861973
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $1.08万
    • 财政年份:
      2014
    • 负责人:
      SHIMIZU Takahiro
    • 依托单位:
    海外基金