Inhibitory role of brain endocannabinoid in central activation of sympatho-adrenomedullary outflow

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We examined the roles of brain endocannabinoid (eCB) in regulation of central activation of sympatho-adrenomedullary (SA) outflow using anesthetized rats. 2-Arachidonoylglycerol (2-AG), an eCB, was endogenously generated in the brain during the central activation of SA outflow. This 2-AG played a promotional role as a precursor of arachidonic acid and also an inhibitory role as an eCB in the activation. These findings suggest that brain 2-AG has bidirectional roles in the central activation of SA outflow. Taken together, brain eCB can be a beneficial target for therapeutic drugs to modulate the outflow.