Elucidation of cellular network for plastic change of vascular smooth muscle cell.

点击翻译按钮获取中文摘要

Vascular smooth muscle cell composing wall of blood vessel contributes the control of blood pressure, by stretching or contracting the cell body. Life style related illness is often originated by atherosclerosis. In such vessel, normal contractile smooth muscle cell changes its property and differentiates into synthetic phenotype. To know the mechanism of the phenotypic change of the cell, we investigated expression level of several genes, and we found that several genes including T-plastin were related to the beginning of atherosclerosis.