Antiinflammatory actions by extracellular acidification and TDAG8

在本研究中，我们研究了TDAG8是否与糖皮质激素诱导的细胞死亡和抑制炎性细胞因子的产生有关。我们发现糖皮质激素地塞米松刺激了TDAG8的表达，并参与了在酸性pH条件下抑制炎症细胞因子的产生。然而，TDAG8不太可能在糖皮质激素诱导的细胞死亡中发挥作用。

In the present study, we examined whether or not TDAG8 is involved in glucocorticoid-induced cell death and inhibition of inflammatory cytokine production. We found that TDAG8 expression is stimulated by glucocorticoid dexamethasone and involved in the inhibition of inflammatory cytokine production at acidic pH. However, it is unlikely that TDAG8 plays a role in the glucocorticoid-inducedcell death.