Biological role of the proton-sensing G-protein coupled receptor TDAG8
Biological role of the proton-sensing G-protein coupled receptor TDAG8
批准号:
20590305
负责人:
ISHII Satoshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
T cell death-associated gene 8 (TDAG8) is an extracellular pH-sensing G protein-coupled receptor. In this study, we show that TDAG8-overexpressing mouse Lewis lung carcinoma (LLC) cells enhance tumor development in animal models. The exogenously expressed TDAG8 rendered LLC cells resistant to acidic culture conditions by PKA and ERK in vitro. Provided that TDAG8 is overexpressed in various tumors and tumor cell lines, our data suggest that TDAG8 enhances tumorigenesis by linking tumor-induced acidity to tumor cell survival/proliferation.
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DOI:
10.1124/mol.108.051003
发表时间:
2009-01
期刊:
Molecular pharmacology
影响因子:
3.6
作者:
[Welch EJ, Naikawadi RP, Li Z, Lin P, Ishii S, Shimizu T, Tiruppathi C, Du X, Subbaiah PV, Ye RD]
通讯作者:
Ye RD
DOI:
10.1074/jbc.m808506200
发表时间:
2009-06-26
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Yanagida, Keisuke, Masago, Kayo, Ishii, Satoshi]
通讯作者:
Ishii, Satoshi
Endothelial cysteinyl leukotriene 2 receptor (CysLT2R) expression mediates myocardial ischemi a-reperfusion injury.
内皮半胱氨酰白三烯 2 受体 (CysLT2R) 表达介导心肌缺血再灌注损伤。
DOI:
--
发表时间:
2008
期刊:
Am. J. Pathol 172
影响因子:
--
作者:
[Jiang, W. et al.]
通讯作者:
W. et al.
ヒト貧毛症の原因となるp2y5/LPA_6変異体の機能解析
引起人类少毛症的p2y5/LPA_6突变体的功能分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[真砂佳代, 柳田圭介, 浜野文三江, 清水孝雄, 石井聡]
通讯作者:
石井聡
細胞外pH感知性G蛋白質共役型受容体TDAG8の癌の進展における役割
细胞外 pH 敏感 G 蛋白偶联受体 TDAG8 在癌症进展中的作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[森功次, 大貫文, 狩野文雄, 林志直, 貞升健志, 永野美由紀, 秋場哲哉, 野口やよい, 仲間晶子, 矢口久美子, 白澤浩, 矢野一好, 石井聡]
通讯作者:
石井聡
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