Analysis of new function of anti-inflammatory protein

抗炎蛋白新功能解析

• 批准号: 22590288
• 负责人: SATO Eisuke
• 金额: $ 2.91万
• 依托单位: Suzuka University of Medical Science (2011-2012)Osaka City University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590288/
• 关键词: アネキシン1; 活性酸素; アポトーシス; ネットーシス; 抗炎症タンパク質; 好中球; 炎症; 細胞外トラップ; アネキシン１; extracellular trap; 抗炎症蛋白; アネキシン; エンドトキシン; NF-kB; トランスジェニックマウス

The anti-inflammatory protein annexin-1 is a potent mediator of inflammation resolution and a 37-kDa member of the annexin family of calcium and phospholipid-binding proteins, expressed constitutively in many cells, including neutrophil. The purpose of this study was to investigate the effect of annexin-1 protein as an endogenous regulator of anti-inflammatory effect and extracellular traps. Annexin1 directly bound to p65 of NF-kB. Annexin 1 also released to extracellular space with nuclear DNA during formation of extracellular traps.

抗炎蛋白膜联蛋白-1是炎症消退的有效介质，是钙和磷脂结合蛋白的膜联蛋白家族的37-kDa成员，在许多细胞（包括中性粒细胞）中组成型表达。本研究的目的是探讨膜联蛋白-1蛋白作为抗炎作用和细胞外陷阱的内源性调节剂的作用。Annexin 1与NF-κ B的p65直接结合。膜联蛋白1在细胞外陷阱形成过程中也随核DNA释放到细胞外。

项目成果

A major protein of mycobacteria possesses ferritin

分枝杆菌的主要蛋白质具有铁蛋白

• 发表时间: 2011
• 期刊: superfamily protein-like activity and protects against DNA damage by Fenton reaction PLoS One
• 作者: M Takatsuka;M Osada-Oka;E Satoh;KKitadokoro;Y Nishiuchi ;M Yoshimura ;M Inoue ;K Iwai ;T Arakawa ;Y Shimoji;H Ogura ;K Kobayashi ;A Rambukkana ;S Matsumoto
• 通讯作者: S Matsumoto

Role of Hypothalamo-Pituitary-Adrenal Axis in the Modulation of Pollinosis induced by Pollen Antigens.

下丘脑-垂体-肾上腺轴在花粉抗原诱导的花粉病调节中的作用。

• 发表时间: 2010
• 期刊: Allergology International
• 影响因子: 6.8
• 作者: Hashimoto;M.;Sato;EF.;Hiramoto;K.,Kasahara;M. Inoue M
• 通讯作者: M. Inoue M

Prevention of scattered light-induced asthenopia and fatigue by a polarized filter Photodermatology

通过偏振滤光片预防散射光引起的眼疲劳和疲劳 Photodermatology

• 发表时间: 2010
• 期刊: Photoimmunology and Photomedicine
• 作者: K Hiramoto;Y Yamate;K Orita;M Jikumaru;E Kasahara;EF. Sato;S Tamura & M Inoue
• 通讯作者: S Tamura & M Inoue

Effect of oxidative stress during repeated ovulation on the structure and functions of the ovary

重复排卵过程中氧化应激对卵巢结构和功能的影响

• 发表时间: 2010
• 期刊: oocytes and their mitochondria Free Radical Biology and Medicine
• 作者: K Miyamoto;EF. Sato*;H Tabata;M Katsuragi;K Hiramoto;E Kasahara;and M Inoue1
• 通讯作者: and M Inoue1

Characterization of Extracellular trap of oral neutrophils

口腔中性粒细胞胞外陷阱的表征

• 发表时间: 2012
• 作者: Sumitani;M;Kasashima;K;Matsugi;J;Endo;H;Sato EF
• 通讯作者: Sato EF