Analysis of new function of anti-inflammatory protein

抗炎蛋白膜联蛋白-1是一种有效的炎症消退介质，是钙和磷脂结合蛋白膜联蛋白家族的37 kda成员，在包括中性粒细胞在内的许多细胞中组成性表达。本研究的目的是研究膜联蛋白-1蛋白作为一种内源性调节剂对抗炎作用和细胞外陷阱的影响。Annexin1直接与NF-kB的p65结合。膜联蛋白1也在胞外陷阱形成过程中随细胞核DNA释放到胞外空间。

The anti-inflammatory protein annexin-1 is a potent mediator of inflammation resolution and a 37-kDa member of the annexin family of calcium and phospholipid-binding proteins, expressed constitutively in many cells, including neutrophil. The purpose of this study was to investigate the effect of annexin-1 protein as an endogenous regulator of anti-inflammatory effect and extracellular traps. Annexin1 directly bound to p65 of NF-kB. Annexin 1 also released to extracellular space with nuclear DNA during formation of extracellular traps.