Analysis of microRNA function on heart and smooth muscles and itsanti-tumor effect using genetically modified mice

点击翻译按钮获取中文摘要

Although accumulating evidence has shown that microRNAs are involved in many human diseases, the molecular mechanisms are still unknown. In this project, we reveal that strong expression of certain microRNAs suppresses the intestine tumor development in the model mice of familial adenomatous polyposis and that cooperation of miRNAs plays pivotal roles in inhibiting protooncogene expression. We further show that key components for biogenesis of a subset of tumor suppressor microRNAs are downregulated in the transgenic tumors. These data indicate the complicated feedback inhibition between micoRNAs and molecules for their biogenesis. This project also demonstrates that their strong expression in mouse heart inducescardiomyopathy, partially clarifying its molecular mechanisms.