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Immune regulation through dendritic cell-specific mTOR pathway

Immune regulation through dendritic cell-specific mTOR pathway
通过树突状细胞特异性 mTOR 通路进行免疫调节
批准号:
22590439
负责人:
MATSUDA Satoshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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英文摘要
Although several reports have suggested the involvement of mTORC1 in development and function of dendritic cells (DCs), its physiological roles remain obscure. By using mTORC1 signal-deficient mice lacking Raptor, an essential component of mTORC1 signal, specifically in DC lineage (referred to here as RaptorDC-/-), we found that impaired mTORC1 signal resulted in the suppression of IL-10 production in intestinal CD11c+CD11b+ DCs. We also found that RaptorDC-/- mice were highly susceptible to dextran sodium sulfate-induced colitis.
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会议论文
Role of class IA PI3K in regulatory T cell function.
IA 类 PI3K 在调节 T 细胞功能中的作用。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Iizasa, E, 藤猪英樹]
通讯作者: 藤猪英樹
関西医科大学付属生命医学研究所生体情報部門 ホームページ
关西医科大学生物医学研究所生物信息学系主页
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
mTOR complex1 is critical for B cell development.
mTOR 复合体1 对于 B 细胞发育至关重要。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Ohtani, M., Fujii, H., Sakai, K., Hoshii, T., Watanabe, T., Koyasu, S., Hirao, A., and Matsuda, S.]
通讯作者: S.
Forced expression of a constitutively active form of p110δ results in decrease of double positive thymocytes during thymocyte development
p110δ组成型活性形式的强制表达导致胸腺细胞发育过程中双阳性胸腺细胞减少
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Yamana, A., et al]
通讯作者: et al
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