Enhancement of utility of imaging mass spectrometry in pathophysiological examination

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The aim of this study is to enhance utility of imaging mass spectrometry (IMS) as new pathophysiological examination. IMS is a two-dimensional MS technique used to visualize the spatial distribution of biomolecules without extraction, purification, separation, or labeling of biological samples. It is important to estimate general versatility of IMS. In this study, we try to visualize the metabolic variation of diseases, including ATGL mutant disease, atherosclerosis, and abdominal aortic aneurysm. We succeed to find some characteristic changes in disease tissues by using IMS.