Establishment of new pathological analysis by imaging mass spectrometry

建立新的成像质谱病理分析方法

• 批准号: 20790419
• 负责人: ZAIMA Nobuhiro
• 金额: $ 2.66万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790419/
• 关键词: 質量顕微鏡法; 病理解析; 脂質代謝異常; 質量顕微鏡; 脂質; 脂質蓄積ミオパチー; 脂肪肝

Biochemical approaches, such as staining, are widely used as pathological analysis. These methods are essential for pathological analysis. However, they have some disadvantages. For example, they cannot be applied to non-targeting analysis. Establishment of new pathological method is important to analyze idiopathic disease. In this study, new pathological analysis using imaging mass spectrometry for non-targeting analysis was established.

生物化学方法，如染色，广泛用于病理分析。这些方法对于病理分析是必不可少的。然而，它们也有一些缺点。例如，它们不能应用于非目标分析。建立新的病理学方法对特发性疾病的分析具有重要意义。在这项研究中，新的病理分析使用成像质谱的非靶向分析建立。

项目成果

Imaging of metabolites by MALDI mass spectrometry.

通过 MALDI 质谱法对代谢物进行成像。

• 发表时间: 2009
• 期刊: Journal of Oleo Science
• 影响因子: 1.5
• 作者: N. Zaima;T. Hayasaka;Naoko Goto;M. Setou
• 通讯作者: M. Setou

The abnormal accumulation of metabolites in neutral lipid storage myopathy caused by adipose triacylglycerol lipase mutation.

脂肪三酰甘油脂肪酶突变引起的中性脂质贮积性肌病代谢物异常积累。

• 发表时间: 2009
• 作者: Zaima;N.;Sugiura;Y.;Hirano;K.;Ohkuma;A.;Okahashi;S.;Noguchi;S.;Nishino;I.;Ibi;T.;Sahashi;K.;Setou;M.
• 通讯作者: M.

Principal component analysis of direct matrix-assisted laser desorption/ionization mass spectrometric data related to metabolites of fatty liver.

与脂肪肝代谢物相关的直接基质辅助激光解吸/电离质谱数据的主成分分析。

• DOI: 10.5650/jos.58.267
• 发表时间: 2009
• 期刊: Journal of oleo science
• 影响因子: 1.5
• 作者: N. Zaima;Y. Matsuyama;M. Setou
• 通讯作者: M. Setou

The pathological analysis of neutral lipid storage myopathy caused by a dipose triacylglycerol lipase mutation.

双性三酰甘油脂肪酶突变所致中性脂质贮积性肌病的病理分析

• 发表时间: 2009
• 作者: Zaima;N.;Sugiura;Y.;Hirano;K.;Ohkuma;A.;Okahashi;S.;Noguchi;S.;Nishino;I.;Ibi;T.;Sahashi;K.;Setou;M.;Nobuhiro Zaima
• 通讯作者: Nobuhiro Zaima

Analysis of Lipid Storage Myopathy (ETFDH mutant or PNPLA2 mutant) by Direct Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

通过直接基质辅助激光解吸/电离质谱法分析脂质沉积性肌病（ETFDH 突变体或 PNPLA2 突变体）

• 发表时间: 2008
• 作者: Zaima;N.;Sugiura;Y.;Hirano;K.;Ohkuma;A.;Okahashi;S.;Noguchi;S.;Nishino;I.;Ibi;T.;Sahashi;K.;Setou;M.;Nobuhiro Zaima;Nobuhiro Zaima
• 通讯作者: Nobuhiro Zaima