ESTABLISH THE INDIVIDUALIZED TREATMENT ON LUNG ADENOCARCINOMA USINGTHE EGFR GENE MUTATION ANALYSIS.

利用 EGFR 基因突变分析建立肺腺癌的个体化治疗。

• 批准号: 22590531
• 负责人: NAKAMURA Yoichi
• 金额: $ 2.58万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590531/
• 关键词: 遺伝子検査学; 非小細胞肺癌; 上皮増殖因子受容体; 遺伝子変異多型; オーダーメイド治療

Intra-tumor heterogeneity of EGFR mutations in patients with mixed-type lung adenocarcinoma was analyzed according to the distribution of histological subtypes. Intra-tumor heterogeneity of EGFR mutations was detected in 9 of 38 tumors, and there was a significant correlation between heterogeneity of EGFR mutations and smoking history (P<0.043).

根据组织学亚型分布分析混合型肺腺癌患者EGFR突变的瘤内异质性。9例EGFR突变在肿瘤内存在异质性，且EGFR突变异质性与吸烟史显著相关（P<0.043）。

项目成果

Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer.

表面活性剂蛋白 D 的血清水平可预测吉非替尼对晚期非小细胞肺癌患者的抗肿瘤活性。

• 发表时间: 2011
• 期刊: Cancer Chemotherapy and Pharmacology
• 影响因子: 3
• 作者: Miyawaki Y;Suzuki A;Fujita J;Maki A;Okuyama E;Murata M;Takagi A;Murate T;Kunishima S;Sakai M;Okamoto K;Matsushita T;Naoe T;Saito H;Kojima T;Yamaguchi H;Atsuo Suzuki;Nakamura Y;Yamaguchi H
• 通讯作者: Yamaguchi H

Phase I/II study of amrubicin and nedaplatin in patients with untreated, advanced non small-cell lung cancer.

氨柔比星和奈达铂治疗未经治疗的晚期非小细胞肺癌患者的 I/II 期研究。

• 发表时间: 2012
• 作者: Senju H;Nakamura Y;Ogawara D;et al.
• 通讯作者: et al.

Phase I and II trials of vinorelbine with carboplatin for patients 75 years of age or older with previously untreated non-small-cell lung cancer.

长春瑞滨联合卡铂治疗 75 岁或以上患有既往未经治疗的非小细胞肺癌患者的 I 期和 II 期试验。

• DOI: 10.1016/j.cllc.2011.11.007
• 发表时间: 2012
• 期刊: Clin Lung Cancer
• 影响因子: 3.6
• 作者: Takatani H;Nakamura Y;Nakatomi K;et al.
• 通讯作者: et al.

Pharmacokinetics of Gefitinib Predicts Antitumor Activity for Advanced Non-small Cell Lung Cancer

• DOI: 10.1097/jto.0b013e3181e59a7b
• 发表时间: 2010-09-01
• 期刊: JOURNAL OF THORACIC ONCOLOGY
• 影响因子: 20.4
• 作者: Nakamura, Yoichi;Sano, Kazumi;Kohno, Shigeru
• 通讯作者: Kohno, Shigeru

Superior vena cava syndrome caused by adult T-cell leukemia/lymphoma: a case report

成人T细胞白血病/淋巴瘤引起的上腔静脉综合征一例报告

• 发表时间: 2011
• 期刊: Acta Med Nagasaki
• 作者: Ikeda T;Nakamura Y;Kohno S;et al
• 通讯作者: et al