POSSIBILITY OF PERSONALIZED TREATMENT IN PATIENTS WITH NON- SMALL CELL LUNG CANCER BY MONITERING OF SERUM CONSENTRATION OF GEFITINIB

通过监测吉非替尼血清浓度对非小细胞肺癌患者进行个性化治疗的可能性

• 批准号: 19590538
• 负责人: NAKAMURA Yoichi
• 金额: $ 2.91万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590538/
• 关键词: 臨床薬理学; 肺癌; 分子標的治療; 上皮成長因子受容体阻害薬; 血中濃度; トラフ値; 分子標的薬

ゲフィチニブで治療を受けた、進行非小細胞肺癌症例のゲフィチニブ血中濃度を測定し、その抗腫瘍活性との相関を統計学的に解析した。その結果、内服開始後8日目の血中濃度(トラフ値)と3日目の血中濃度(トラフ値)の比が、ゲフィチニブの抗腫瘍活性と相関することが明らかとなった。一方で、有害事象と血中濃度の相関は統計学的に認めなかった。

The serum concentrations of the two drugs were measured and the correlation between the two drugs was analyzed statistically. Results: The ratio of serum concentration at 8 days after oral administration to serum concentration at 3 days after oral administration, the correlation between serum concentration and anti-tumor activity, and the correlation between serum concentration and anti-tumor activity. The correlation between blood concentration and adverse events is statistically significant.

项目成果

Irinotecan and cisplatin with concurrent split- course radiotherapy in locally advanced nonsmall-cell lung cancer

伊立替康和顺铂联合分程放疗治疗局部晚期非小细胞肺癌

• 发表时间: 2007
• 期刊: a multiinstitutional phase 2 study. Cancer 110
• 作者: Fukuda M;Soda H;Nakamura Y;et.al.
• 通讯作者: et.al.

Nagasaki Thoracic Oncology Group : Phase I study of vinorelbine and irinotecan in previously untreated patients with advanced non- small cell lung cancer

长崎胸部肿瘤组：针对既往未经治疗的晚期非小细胞肺癌患者进行长春瑞滨和伊立替康的 I 期研究

• 发表时间: 2008
• 期刊: Cancer Chemothe Pharmacol 62
• 作者: Tomonaga N;Nakamura Y;Soda H,et.al.
• 通讯作者: Soda H,et.al.

抗悪性腫瘍治療薬マニュアル

抗恶性肿瘤治疗药物说明书

• 发表时间: 2007
• 作者: 島田美智子;保嶋実;神崎恒一;中村ら
• 通讯作者: 中村ら

Methylation status of breast cancer resistance protein detected by methylation-specific polymerase chain reaction analysis is correlated inversely with its expression in drug-resistant lung cancer cells

• DOI: 10.1002/cncr.23285
• 发表时间: 2008-03-01
• 期刊: CANCER
• 影响因子: 6.2
• 作者: Nakano, Hirofumi;Nakamura, Yoichi;Tsukamoto, Kazuhiro
• 通讯作者: Tsukamoto, Kazuhiro

Phase I study of irinotecan and gemcitabine in previously untreated patients with advanced non-small cell lung cancer.

• DOI: 10.1093/jjco/hym030
• 发表时间: 2007-05
• 期刊: Japanese journal of clinical oncology
• 影响因子: 2.4
• 作者: H. Takatani;H. Soda;Yoichi Nakamura;A. Kinoshita;M. Fukuda;S. Nagashima;M. Fukuda;Y. Soejima;H. Nakano;M. Oka;S. Kohno