Molecular epidemiology of metabolic syndrome and atherosclerosis initiating from genome wide association study
Molecular epidemiology of metabolic syndrome and atherosclerosis initiating from genome wide association study
批准号:
22590547
负责人:
MURAMATSU Masaaki
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
我们评估了日本人群中代谢综合征和心肌梗死的易感基因/变异,这些易感基因/变异最初是在西方人群中发现的。我们在不同的代谢综合征表型中复制了他们的一些结果,并在日本队列中发现了新的基因-环境和基因-基因相互作用。在西方和日本人群中,心肌梗死危险基因的作用可能不同。
英文摘要
We evaluated susceptibility genes/variations for metabolic syndrome and myocardial infarction in Japanese population, which were primarily found by GWAS in western population. We replicated some of their results in different phenotypes of metabolic syndrome, and also found novel gene-environment and gene-gene interactions in Japanese cohort. The effect of risk gene for myocardial infarction may be different between western and Japanese population.
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DOI:
10.1016/j.atherosclerosis.2012.01.003
发表时间:
2012-04-01
期刊:
ATHEROSCLEROSIS
影响因子:
5.3
作者:
[Ikeda, Shinobu, Tanaka, Noriko, Sawabe, Motoji]
通讯作者:
Sawabe, Motoji
Respond to "Gene x Lifestyle Interactions"
回复“基因x生活方式互动”
DOI:
--
发表时间:
2010
期刊:
Am.J.Epidemiol
影响因子:
--
作者:
[Miyaki K, et al.]
通讯作者:
et al.
Association of a cyclin-dependent kirnase 5 regulatory subunit-associated protein 1-like 1(CDKAL1)polymorphism with elevated hemoglobin Alc levels and the prevalence of metabolic syndrome in Japanese men
细胞周期蛋白依赖性激酶 5 调节亚基相关蛋白 1 样 1 (CDKAL1) 多态性与日本男性血红蛋白 Alc 水平升高和代谢综合征患病率的关联
DOI:
--
发表时间:
2010
期刊:
Am.J.Epidemiol
影响因子:
--
作者:
[Miyaki K, et al.]
通讯作者:
et al.
J Atheroscler Thromb
动脉粥样硬化血栓杂志
DOI:
--
发表时间:
2012
期刊:
Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese
影响因子:
--
作者:
[Ko MK, Ikeda S, Mieno-Naka M, Arai T, Zaidi SA, Sato N, Muramatsu M,Sawabe M]
通讯作者:
Muramatsu M,Sawabe M
DOI:
10.1038/jhh.2011.50
发表时间:
2012-07-01
期刊:
JOURNAL OF HUMAN HYPERTENSION
影响因子:
2.7
作者:
[Miyaki, K., Htun, N. C., Shimbo, T.]
通讯作者:
Shimbo, T.
共 6 条
Prevention of metabolic syndrome and atherosclerosis by personal genome information
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批准号:26460741
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2014
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负责人:MURAMATSU Masaaki
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依托单位:
海外基金