Role of macrophage migration inhibitory factor in esophagitis and esophageal tumor

巨噬细胞迁移抑制因子在食管炎及食管肿瘤中的作用

• 批准号: 22590675
• 负责人: OHKAWARA Tatsuya
• 金额: $ 2.33万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590675/
• 关键词: 好酸球性食道炎; マクロファージ遊走阻止因子; ワクチン治療; 逆流性食道炎; 食道炎; 好酸球; 食道腫瘍; MIF活性阻害剤

We basically investigated the role of macrophage migration inhibitory factor(MIF) in esophageal diseases. The expression of MIF protein in the esophagus of rats was less than that of stomach and intestine in rat. We developed MIF DNA vaccine, which is a novel MIF inhibitor, and this vaccine ameliorated the severity of intestinal inflammation in mice. In the study using MIF knockout mice, MIF did not affect the level of gastric acid-secretion in mice. MIF knockout mice were resistant to drug-induced gastrointestinal inflammation, partly via induction of heat shock protein. Treatment with MIF inhibitor suppressed eosinophil infiltrate in the esophagus of mice.

初步探讨了巨噬细胞移动抑制因子（MIF）在食管疾病中的作用。MIF在大鼠食管中的表达低于胃和肠。我们研制了一种新型的MIF抑制剂--MIF DNA疫苗，该疫苗可减轻小鼠肠道炎症的严重程度。在使用MIF敲除小鼠的研究中，MIF不影响小鼠的胃酸分泌水平。MIF基因敲除小鼠对药物诱导的胃肠道炎症具有抵抗力，部分原因是通过诱导热休克蛋白。用MIF抑制剂处理抑制小鼠食管中的嗜酸性粒细胞浸润。

项目成果

DNA vaccination targeting macrophage migration inhibitory factor prevents murine experimental colitis

• DOI: 10.1111/j.1365-2249.2010.04277.x
• 发表时间: 2011-01
• 期刊: Clinical & Experimental Immunology
• 影响因子: 4.6
• 作者: T. Ohkawara;T. Ohkawara;Yoshikazu Koyama;S. Onodera;Hiroshi Takeda;Mototsugu Kato;Masahiro Asaka;Jun Nishihira

Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice

• DOI: 10.1016/j.intimp.2010.12.009
• 发表时间: 2011-04-01
• 期刊: INTERNATIONAL IMMUNOPHARMACOLOGY
• 影响因子: 5.6
• 作者: Ohkawara, Tatsuya;Takeda, Hiroshi;Asaka, Masahiro
• 通讯作者: Asaka, Masahiro