Development of mucosal vaccine based on mucosal immune system enhancing activity of Kampo medicines.

基于粘膜免疫系统增强汉方药物活性的粘膜疫苗的开发。

• 批准号: 22590672
• 负责人: MIYATA Takeshi
• 金额: $ 2.75万
• 依托单位: Sojo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590672/
• 关键词: 漢方薬; インフルエンザ; 東洋医学; 粘膜ワクチン; アジュバント

Intranasal administration of hemagglutinin vaccine with an adjuvant is effective for protection against influenza virus infection. In this study, we found that Kampo medicines, which enhance mucosal immune system, are used for an oral adjuvant. Maoto increased IgA, IgG antibody in bronchoalveolar lavage fluid and serum. Maoto also showed production of virus-specific antibody after intranasal vaccination.

鼻内接种血凝素疫苗和佐剂可有效预防流感病毒感染。在这项研究中，我们发现增强粘膜免疫系统的汉方药物可用作口服佐剂。Maoto可使支气管肺泡灌洗液和血清中伊加、IgG抗体升高。Maoto在鼻内接种后也显示出病毒特异性抗体的产生。

项目成果

Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors elucidation using organic hippocampal slice cultures.

使用有机海马切片培养物阐明内源性乙酰胆碱通过刺激毒蕈碱 M(1) 受体来挽救 NMDA 诱导的长期海马细胞损伤。

• 发表时间: 2013
• 期刊: Eur J Pharmacol
• 影响因子: 5
• 作者: Inada C;Thi Le X;Tsuneyama K;Fujiwara H;Miyata T;Matsumoto K.
• 通讯作者: Matsumoto K.

Roles of antioxidants and heat shock protein induces as an antifatigue effects induced by health supplements

抗氧化剂和热休克蛋白的作用作为保健品引起的抗疲劳作用

• 发表时间: 2010
• 作者: T.Kawabe;T Hano;T Ueyama;Y Tsuruo;横溝和美,周 建融,宮田 健
• 通讯作者: 横溝和美,周 建融,宮田 健

Diabetes-Induced Central Cholinergic Neuronal Loss and Cognitive Deficit Are Attenuated by Tacrine and a Chinese Herbal Prescription, Kangen-Karyu: Elucidation in Type 2 Diabetes db/db Mice

• DOI: 10.1254/jphs.11115fp
• 发表时间: 2011-12-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Zhao, Qi;Matsumoto, Kinzo;Yokozawa, Takako
• 通讯作者: Yokozawa, Takako

New spirostanol glycosides from Solanum nigrum and S. jasminoides

来自龙葵和茉莉花的新螺甾醇糖苷

• DOI: 10.1007/s11418-012-0637-z
• 发表时间: 2012
• 期刊: J Nat Med
• 作者: ルクババスレン バトトプシン;岡孝和;須藤信行;林晴男;Ohno M
• 通讯作者: Ohno M

Identification and Characterization of Component Organic and Glycosidic Acids of Crude Resin Glycoside Fraction from Calystegia soldanella

水萼粗树脂苷组分有机酸和苷酸的鉴定与表征

• DOI: 10.1248/cpb.59.1163
• 发表时间: 2011
• 期刊: Chemical and Pharmaceutical Bulletin
• 影响因子: 1.7
• 作者: Sota Hayashida;Takakazu Oka;Takashi Mera;Haruo Hayashi;Sadatoshi Tsuji;Takigawa A
• 通讯作者: Takigawa A