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Development of mucosal vaccine based on mucosal immune system enhancing activity of Kampo medicines.

Development of mucosal vaccine based on mucosal immune system enhancing activity of Kampo medicines.
基于粘膜免疫系统增强汉方药物活性的粘膜疫苗的开发。
批准号:
22590672
负责人:
MIYATA Takeshi
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Intranasal administration of hemagglutinin vaccine with an adjuvant is effective for protection against influenza virus infection. In this study, we found that Kampo medicines, which enhance mucosal immune system, are used for an oral adjuvant. Maoto increased IgA, IgG antibody in bronchoalveolar lavage fluid and serum. Maoto also showed production of virus-specific antibody after intranasal vaccination.
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Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors elucidation using organic hippocampal slice cultures.
使用有机海马切片培养物阐明内源性乙酰胆碱通过刺激毒蕈碱 M(1) 受体来挽救 NMDA 诱导的长期海马细胞损伤。
DOI: --
发表时间: 2013
期刊: Eur J Pharmacol
影响因子: 5
作者: [Inada C, Thi Le X, Tsuneyama K, Fujiwara H, Miyata T, Matsumoto K.]
通讯作者: Matsumoto K.
Roles of antioxidants and heat shock protein induces as an antifatigue effects induced by health supplements
抗氧化剂和热休克蛋白的作用作为保健品引起的抗疲劳作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [T.Kawabe, T Hano, T Ueyama, Y Tsuruo, 横溝和美,周 建融,宮田 健]
通讯作者: 横溝和美,周 建融,宮田 健
DOI: 10.1254/jphs.11115fp
发表时间: 2011-12-01
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
影响因子: 3.5
作者: [Zhao, Qi, Matsumoto, Kinzo, Yokozawa, Takako]
通讯作者: Yokozawa, Takako
New spirostanol glycosides from Solanum nigrum and S. jasminoides
来自龙葵和茉莉花的新螺甾醇糖苷
DOI: 10.1007/s11418-012-0637-z
发表时间: 2012
期刊: J Nat Med
影响因子: --
作者: [ルクババスレン バトトプシン, 岡孝和, 須藤信行, 林晴男, Ohno M]
通讯作者: Ohno M
22
    DNA macromolecule as a vaccine antigen scaffold for organization of the antigens into repetitively ordered arrays
    Construction of immunologic tolerance induction biological defense molecule using heteropentameric cholera toxin B subunit molecules
    • 批准号:
      19780227
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.3万
    • 财政年份:
      2007
    • 负责人:
      MIYATA Takeshi
    • 依托单位:
    Pharmacological study to cure mibyo, disease-oriented state
    • 批准号:
      19390193
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.81万
    • 财政年份:
      2007
    • 负责人:
      MIYATA Takeshi
    • 依托单位:
    Basic study to develop a new therapeutic drug in chronic obstructive pulmonary disease
    • 批准号:
      15390030
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.6万
    • 财政年份:
      2003
    • 负责人:
      MIYATA Takeshi
    • 依托单位:
    海外基金