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DNA macromolecule as a vaccine antigen scaffold for organization of the antigens into repetitively ordered arrays

DNA macromolecule as a vaccine antigen scaffold for organization of the antigens into repetitively ordered arrays
DNA大分子作为疫苗抗原支架,用于将抗原组织成重复有序的阵列
批准号:
24790404
负责人:
MIYATA Takeshi
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
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英文摘要
We have developed a new technology to enhance immune responses by generating complex which composed DNA-binding protein fused vaccine antigen and DNA (DBP-Ag/DNA). In this system, DNA was used as scaffold material, not genetic information. Vaccine efficacy of the DBP-Ag/DNA complex was evaluated using an ookinete surface protein of Plasmodium vivax, Pvs25. The DBP-Ag/DNA complex immunized mice were conferred a high immune response compared to Pvs25 alone immunized group. This system may be a promising approach for development of subunit vaccines against malaria.
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DOI: --
发表时间: 2017
期刊:
影响因子: --
作者: [Remil Linggatong Galay, Takeshi Miyata, Rika Umemiya-Shirafuji, Hiroki Maeda, Kodai Kusakisako, Masami Mochizuki, KozoFujisaki, Tetsuya Tanaka]
通讯作者: Tetsuya Tanaka
Induction of early protective immunity against pulmonary Mycobcterium tuberculosis infection in mice by combination of BCG priming vaccine and boosting mucosal vaccine with a recombinant mycobacterial antigen
卡介苗初免疫苗和重组分枝杆菌抗原加强粘膜疫苗联合诱导小鼠针对肺结核分枝杆菌感染的早期保护性免疫
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Masayuki Fukui, Masayuki Umemura, Takeshi Miyata, Tetsuya Harakuni, Takeshi Arakawa, Goro Matsuzaki]
通讯作者: Goro Matsuzaki
三日熱マラリア伝搬阻止ワクチン候補抗原(Pvs25)の反復整列化とそのワクチン効果
抑制间日疟传播的疫苗候选抗原(Pvs25)的重复排列及其疫苗功效
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [原國哲也, 山田清太郎, 宮田健, 山口類, 玉城志博, 坪井敬文, Jetsumon Sattabongkot, 橘真由美, 鳥居本美, 新川武]
通讯作者: 新川武
コレラトキシンB鎖と三日熱マラリア伝搬阻止ワクチン抗原Pvs25の融合体構築とそのワクチン機能解析
霍乱毒素B链与抑制间日疟传播疫苗抗原Pvs25融合蛋白的构建及其疫苗功能分析
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [原國哲也, 宮田健, 坪井敬文, Jetsumon Sattabongkot, 橘真由美, 鳥居本美, 新川武]
通讯作者: 新川武
17
    Development of mucosal vaccine based on mucosal immune system enhancing activity of Kampo medicines.
    • 批准号:
      22590672
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2010
    • 负责人:
      MIYATA Takeshi
    • 依托单位:
    Construction of immunologic tolerance induction biological defense molecule using heteropentameric cholera toxin B subunit molecules
    • 批准号:
      19780227
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.3万
    • 财政年份:
      2007
    • 负责人:
      MIYATA Takeshi
    • 依托单位:
    Pharmacological study to cure mibyo, disease-oriented state
    • 批准号:
      19390193
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.81万
    • 财政年份:
      2007
    • 负责人:
      MIYATA Takeshi
    • 依托单位:
    Basic study to develop a new therapeutic drug in chronic obstructive pulmonary disease
    • 批准号:
      15390030
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.6万
    • 财政年份:
      2003
    • 负责人:
      MIYATA Takeshi
    • 依托单位:
    海外基金