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Quantitative Analysis of Left Ventricular Deformation After Immunoadsorption Therapy for Patients with Dilated Cardiomyopathy and Severe Congestive

扩张型心肌病合并严重充血患者免疫吸附治疗后左心室变形的定量分析

基本信息

批准号：
22590774
负责人：
KOYAMA Jun
金额：
$ 3.08万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590774/
关键词：
心不全免疫吸着療法超音波免疫吸着法

项目摘要

Various studies with a limited number of patients suffering from dilated cardiomyopathy (DCM). However little is known about the global and regional LV function after IA therapy using speckle tracking echocardiography (STE), which has been validat ed the accuracy compared with LVEF. Consecutive 6 patients with DCM (New York Heart Association III-IV, LVEF < 35%) underewent standard, Doppler flow, and STE. Basal, mid-, apical short axis views and apical 3 views were used to examine circumferential, radial, and longitudinal strains and LV torsion. Echocardiographic assesment was perfomed at baseline, 1 week, 1, 3, 6, and 12 months after IA therapy. During 12-month follow-up, there were no significant differences in LVEF (pre 30.67 ± 8.1, 1 month 29.17 ± 7.1, p = NS), LV end-diastolic volume (pre 164.0 ± 90.2, 1 month 138.5 ± 57.9, p = NS), LV end-systolic volume (pre 115.7 ± 73.4, 1month 90.8± 56.4, p = NS). As to the values of STE , there were also no significant differences in longitudinal, circumferential, and radial strain and LV torsion. In conclusion, IA therapy did not improve LVEF, LV volume, LV longitudinal, circumferential, and radial strain and LV torsion in DCM.

对数量有限的扩张型心肌病(DCM)患者进行的各种研究。然而，斑点追踪超声心动图(STE)对IA治疗后的整体和局部左心功能了解甚少，与LVEF相比，其准确性已得到验证。连续6例DCM患者(纽约心脏协会III-IV，LVEF和Lt；35%)均低于标准、多普勒血流和ST段抬高。分别采用基础、中轴、心尖短轴切面和心尖3个切面，检测周向、径向和纵向应变及左心室扭转。分别于治疗前、治疗后1周、3个月、6个月和12个月进行超声心动图检查。随访12个月，左心室射血分数(前30.67±8.1，1个月2 9.17±7.1，p=NS)、左心室舒张末容量(前164.0±90.2，1个月138.5±5 7.9，p=NS)、左心室收缩末期容量(前115.7±73.4，1个月90.8±5 6.4，p=NS)差异无统计学意义。STE值在纵向、周向、径向应变和LV扭转方面也无显著差异。结论：IA治疗不能改善DCM患者的LVEF、LV容量、LV纵向、周向、径向应变和LV扭转。