Personalized cancer medicine for non-small cell lung cancer

点击翻译按钮获取中文摘要

We developed a reliable, reproducible, and simple orthotopic model for human lung cancer cell line using nude mice, multiple models with different biologic and clinical phenotypes may allow a better understanding of the behavior and treatment effects. We also showed correlation of the biomarker expression between biopsy specimens and surgical specimens assessed by IHC. Finally, we conducted a phase I/II clinical study of combination chemotherapy with EGFR-tyrosine kinase inhibitor and cytotoxic agent for recurrent lung cancer.These results lead to individualized chemotherapy and benefit patients with advanced non-small-cell lung cancer.