Mode of existence and cell division and multi-drug resistance of progenitor-like cells in distal area of S3 segment of proximal tubules
Mode of existence and cell division and multi-drug resistance of progenitor-like cells in distal area of S3 segment of proximal tubules
批准号:
22590884
负责人:
FUJIGAKI Yoshihide
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We investigated the possibility that the initially proliferating cells (target cells) which are responsible for recovering the damaged proximal tubules are progenitor-like cells in tubules in acute kidney injury model of rat. The target cells showed unequal cell division which is characterized in stem cells and more than one such a cell located in the same nephron. ABC transporter as multiple drug resistant phenotype in the isolated target cells were not different from those in other proximal tubular cells, but the target cells were resistant to urnaly acetate and 5-fluorouracil. The data support the possibility that the target cells are tubular epithelial progenitor-like cells.
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AKIにおける遺伝子治療の可能性. 特集 急性腎障害(AKI)―概念の確認から、さらなる予後改善を目指して
AKI基因治疗的可能性。专题:急性肾损伤(AKI)——从概念确认到进一步改善预后
DOI:
--
发表时间:
2012
期刊:
内科
影响因子:
--
作者:
[Inazi R, et al., 藤垣嘉秀]
通讯作者:
藤垣嘉秀
AKI (Acute kidney injury)
AKI(急性肾损伤)
DOI:
--
发表时间:
2012
期刊:
日本腎臓学会誌
影响因子:
--
作者:
[榊原ゆみ, 稲瀬直彦, 星野仁彦, 古市 賢吾,和田 隆志, 藤垣嘉秀]
通讯作者:
藤垣嘉秀
Hepatocyte growth factor /c-Metsignaling contributes to the acquiredresistance after acute subclinicalkidney damage with uranyl acetate.
肝细胞生长因子/c-Met信号传导有助于醋酸双氧铀造成急性亚临床肾损伤后的获得性耐药。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[藤倉知行, 戸川証, Yuan Sun, 藤垣嘉秀]
通讯作者:
藤垣嘉秀
急性腎不全における尿細管修復過程と再生
急性肾功能衰竭的肾小管修复过程和再生
DOI:
--
发表时间:
2011
期刊:
Nephrology Frontier
影响因子:
--
作者:
[榊原ゆみ, 森本耕三, 吉山崇, 倉島篤行, 藤原永年, 稲瀬直彦, 石井則久, 星野仁彦, 藤垣嘉秀]
通讯作者:
藤垣嘉秀
Acquired resistance to rechallenge injury in rats that recovered from mild renal damage induced by uranyl acetate : accelerated proliferation and hepatocyte growth factor/c-Met axis.
从醋酸双氧铀引起的轻度肾损伤中恢复的大鼠获得了对再攻击损伤的抵抗力:加速增殖和肝细胞生长因子/c-Met轴。
DOI:
10.1007/s10157-011-0453-x
发表时间:
2011
期刊:
Clin Exp Nephrol
影响因子:
2.3
作者:
[Sun Y, Fujigaki Y, Sakakima M, Fujikura T, Togawa A, Huang Y, Hishida A]
通讯作者:
Hishida A
共 22 条
Roles of progenitor-like cells and infiltrative macrophages on renal tubular regeneration and their application on cell therapy
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批准号:19590945
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:FUJIGAKI Yoshihide
-
依托单位:
Identification of tubular epithelial stem cells and their roles on recovery from acute renal failure
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批准号:15590848
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:FUJIGAKI Yoshihide
-
依托单位:
Roles of interstitial cells on the recovery process from acute renal failure
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批准号:13671107
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:FUJIGAKI Yoshihide
-
依托单位:
海外基金