Missing link between metabolic syndrome and chronic kidney disease.?Role of asymmetric dimethylarginine-

代谢综合征和慢性肾脏病之间缺失联系。？不对称二甲基精氨酸的作用-

• 批准号: 22590903
• 负责人: OKUDA Seiya
• 金额: $ 2.83万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590903/
• 关键词: メタボリック症候群; インスリン抵抗性; 慢性腎臓病; ADMA; 内皮障害; 心腎連関; CKD; 内皮機能障害; DDAH; 微量アルブミン尿; 脂肪細胞

Metabolic syndrome (MetS) is a strong risk factor for the initiation and development of chronic kidney disease (CKD). One possible factor that could explain this link seems to be endothelial dysfunction (ED). In CKD patients, ADMA levels were associated with metabolic factors and eGFR. Further, increased ADMA levels were associated with surrogate markers for cardiovascular disease as well as annual reduction rates of GFR. Animal models of MetS revealed that dysregulation of DDAH, an enzyme for ADMA could account for ADMA elevation, and therefore could contributed to the development and progression of cardiovascular disease as well as renal injury in Mets.

代谢综合征（METS）是慢性肾脏疾病（CKD）起始和发育的强大风险因素。可以解释此链接的一个可能因素似乎是内皮功能障碍（ED）。在CKD患者中，ADMA水平与代谢因子和EGFR有关。此外，ADMA水平升高与心血管疾病的替代标记以及GFR的年减少率有关。 Mets的动物模型表明，DDAH的失调，ADMA的酶可能会导致ADMA升高，因此可能有助于心血管疾病的发展和发展以及大都会的肾脏损伤。

项目成果

Tissue level of AGEsis an independent determinant of high sensitive Creactive proteinlevel in HD patients

AGE的组织水平是HD患者高敏Creactive蛋白水平的独立决定因素

• 发表时间: 2011
• 期刊: Nephrology
• 影响因子: 2.5
• 作者: Kanaoka T;et al;Seiay Okuda
• 通讯作者: Seiay Okuda

New pathways to renal damage : role of ADMA in retarding renal disease progression

肾损伤的新途径：ADMA 在延缓肾病进展中的作用

• 发表时间: 2010
• 期刊: Journal of Nephrology
• 影响因子: 3.4
• 作者: Wakui H;Tamura K;Matsuda M;Bai Y;Dejima T;Shigenaga A;Masuda S;Azuma K;Maeda A;Hirose T;Ishigami T;Toya Y;Yabana M;Minamisawa S;Umemura S;佐々木環.;Seiya Okuda
• 通讯作者: Seiya Okuda

Involvement of DDAH-ADMA axis in accelerated renal injury in acute ischemia-reperfusion injury.

DDAH-ADMA 轴参与急性缺血再灌注损伤加速肾损伤。

• 发表时间: 2010
• 作者: Okuda S;et al.
• 通讯作者: et al.

Role of asymmetric dimetylarginine in cardiorenal syndrome.

不对称二甲基精氨酸在心肾综合征中的作用。

• 期刊: Current Pharmaceutical Design
• 影响因子: 3.1
• 作者: Ueda S;Yamagishi S;Yokoro M;Okuda S.
• 通讯作者: Okuda S.

Role of asymmetric dimethylargine in cardiorenal syndrome

不对称二甲基精氨酸在心肾综合征中的作用

• 发表时间: 2013
• 期刊: Current Pharmaceutical Design
• 影响因子: 3.1
• 作者: Ueda S;et al.
• 通讯作者: et al.