Missing link between metabolic syndrome and chronic kidney disease.?Role of asymmetric dimethylarginine-

代谢综合征和慢性肾脏病之间缺失联系。？不对称二甲基精氨酸的作用-

• 批准号: 22590903
• 负责人: OKUDA Seiya
• 金额: $ 2.83万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590903/
• 关键词: メタボリック症候群; インスリン抵抗性; 慢性腎臓病; ADMA; 内皮障害; 心腎連関; CKD; 内皮機能障害; DDAH; 微量アルブミン尿; 脂肪細胞

Metabolic syndrome (MetS) is a strong risk factor for the initiation and development of chronic kidney disease (CKD). One possible factor that could explain this link seems to be endothelial dysfunction (ED). In CKD patients, ADMA levels were associated with metabolic factors and eGFR. Further, increased ADMA levels were associated with surrogate markers for cardiovascular disease as well as annual reduction rates of GFR. Animal models of MetS revealed that dysregulation of DDAH, an enzyme for ADMA could account for ADMA elevation, and therefore could contributed to the development and progression of cardiovascular disease as well as renal injury in Mets.

代谢综合征（MetS）是慢性肾脏病（CKD）发生和发展的一个强烈危险因素。可以解释这种联系的一个可能因素似乎是内皮功能障碍（ED）。在 CKD 患者中，ADMA 水平与代谢因素和 eGFR 相关。此外，ADMA 水平的升高与心血管疾病的替代标志物以及 GFR 的年下降率相关。 MetS 的动物模型显示，DDAH（一种 ADMA 酶）的失调可能导致 ADMA 升高，因此可能导致 Mets 心血管疾病以及肾损伤的发生和进展。

项目成果

Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD).

• DOI: 10.1016/j.lfs.2009.03.018
• 发表时间: 2009-06
• 期刊: Life sciences
• 影响因子: 6.1
• 作者: S. Ueda;S. Yamagishi;Yuriko Matsumoto;Y. Kaida;Ayako Fujimi-Hayashida;Kiyomi Koike;Hideharu Tanaka;K. Fukami;S. Okuda

Tissue level of AGEsis an independent determinant of high sensitive Creactive proteinlevel in HD patients

AGE的组织水平是HD患者高敏Creactive蛋白水平的独立决定因素

• 发表时间: 2011
• 期刊: Nephrology
• 影响因子: 2.5
• 作者: Kanaoka T;et al;Seiay Okuda
• 通讯作者: Seiay Okuda

New pathways to renal damage : role of ADMA in retarding renal disease progression

肾损伤的新途径：ADMA 在延缓肾病进展中的作用

• 发表时间: 2010
• 期刊: Journal of Nephrology
• 影响因子: 3.4
• 作者: Wakui H;Tamura K;Matsuda M;Bai Y;Dejima T;Shigenaga A;Masuda S;Azuma K;Maeda A;Hirose T;Ishigami T;Toya Y;Yabana M;Minamisawa S;Umemura S;佐々木環.;Seiya Okuda
• 通讯作者: Seiya Okuda

A new vasculitis activity score for predicting death in MPO-ANCA associated vasculitis patients

用于预测 MPO-ANCA 相关血管炎患者死亡的新血管炎活动评分

• 发表时间: 2012
• 期刊: Am J Nephrrol
• 作者: Tamura K;Kanaoka T;Ohsawa M;Haku S;Azushima K;Maeda A;Dejima T;Wakui H;Ozawa M;Shigenaga A;Umemura S;Seiya Okuda
• 通讯作者: Seiya Okuda

New pathways to renal damage: role of ADMA in retarding renal disease progression.

肾损伤的新途径：ADMA 在延缓肾病进展中的作用。

• 发表时间: 2010
• 期刊: J Nephrol.
• 作者: Ueda S;Yamagishi S;Okuda S.
• 通讯作者: Okuda S.