Effect of RAGE on the interaction between osteoblasts and osteoclasts and its epigenetic regulation

AGEs受体（AGEs）与糖尿病并发症的进展有关。我们感兴趣的是确定骨代谢的影响。在使用前成骨细胞RAW 264.7细胞和前成骨细胞MC 3 T3-E1细胞的实验中，配体诱导的RAGE活化通过成骨细胞分泌的因子刺激破骨细胞生成。每个NFATc 1-下游基因有不同的时间，其峰值表达，这表明每个NFATc 1靶基因的阶段特异性调节。

The receptor for AGEs (RAGE) is implicated in the progression of diabetic complications. We were interested in determining the influence of RAGE on bone metabolism. In the experiments using pre-osteoclastic RAW264.7 cells and pre-osteoblastic MC3T3-E1 cells, ligand-induced activation of RAGE-stimulates osteoclastogenesis through factors secreted from osteoblasts. Each NFATc1-downstream gene has a different timing of its peak expression, suggesting stage-specific regulation of the each NFATc1 target genes.