Regulatory mechanisms of hepcidin, the central regulator of body iron homeostasis

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The purpose of this study was to clarify the pathogenesis of iron disorders through basic and clinical studies of iron metabolism-associated molecules such as hepcidin and ferritin. We identified that hepcidin expression by hepatoma cells was affected by microenvironmental pH. We also found that iron storage protein H-ferritin was selectively taken up by erythroid cells through transferrin receptor 1. Furthermore, we demonstrated that pre-transplant hyperferritinemia was a risk factor for bacterial infection and disease relapse after allogenic stem cell transplantation.