Construction of the control system of activity of innate immune system.: New cure development of an intractable granulomatous disease.

为了应用于克罗恩病或结节病的医学治疗，产生了背景的低NOD家族的突变体。此外，还制备了显性负性突变体，并将其应用于Blau综合征的治疗。阐明了NOD家族活性控制剂的凋亡诱导能力。作为结节病的原因，阐明了由对痤疮丙酸杆菌的免疫应答不足引起的Th-1和Th-17平衡的异常。NOD 2在造血干细胞向髓系细胞分化阶段的异常，清楚地表明它与白血病症状的发展有关。

In order to apply to the medical treatment of Crohn's disease or sarcoidosis, the mutant of low NOD family of a background was produced. Moreover, the dominant negative mutantwas produced and the application to the medical treatment of Blau syndrome was aimed at. Apoptosis induction ability of the NOD family active control agent was clarified. As a cause of sarcoidosis, the abnormalities in balance of Th-1 and Th-17 by the immune response insufficiency to P. acne were clarified. The abnormalities of NOD2 of the differentiation stage from blood stem cell to myeloid cell showed clearly that it relates to development of symptoms of leukemia.