Identification of signals involved melanomagenesis and melanoma growth, expecially, UV-induced melanoma formation

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Fair skin caucasians with red hair are more susceptible to UV-induced melanoma. We generated melanoma model mouse harboring epidermal melanocytes with different melanin species, then irradiated with UVB or UVA. UVA irradiation did not accelerate melanoma formation, however, UVB did so. Especially, pheomlanin, which is produced more in caucasians. Pheomelanin containing epidermis showed prolonged CPDs after UVB irradiation. DNA repair-deficient mouse also showed early melanoma formation. These results indicate that DNA damages caused by UVB and pheomelanin could be a trigger of melanoma formation.