Epigenetics abnormalities andescape fromthe immune system in epidermal keratinocytes

表皮角质形成细胞的表观遗传学异常和免疫系统逃避

• 批准号: 22591224
• 负责人: KUBO Yoshiaki
• 金额: $ 2.83万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591224/
• 关键词: 皮膚腫瘍学; 表皮細胞; 腫瘍化; エピジェネティクス; 脂漏性角化症; 皮膚線維腫; 隆起性皮膚線維肉腫; FGFR3; FOXN1; PD-L; 有棘細胞癌

We examined the expression of all fibroblast growth factor receptors (FGFR1-4), their ligands (FGF1, 2, 9), and forkhead box N1 (FOXN1) in dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) by immunohistochemical analysis. Overexpression of FGFR3 and FOXN1 was observed in the epidermalregions of DF, and overexpression of FGF2 and FGFR4 was observed in the tumor lesions of DF. These expression patterns were in contrast with those of DFSP. We suppose tumor cells of DF may produce epigenetic changes in the epidermal regions of DF.

我们用免疫组化方法检测了皮肤纤维瘤（DF）和隆突性皮肤纤维肉瘤（DFSP）中所有成纤维细胞生长因子受体（FGFR 1 -4）及其配体（FGF 1，2，9）和叉头盒N1（FOXN 1）的表达。FGFR 3和FOXN 1在DF的表皮区呈高表达，FGF 2和FGFR 4在DF的肿瘤区呈高表达。这些表达模式与DFSP相反。我们推测DF的肿瘤细胞可能在DF的表皮区域产生表观遗传变化。

项目成果

The involvement of fibroblast growth factor receptor signaling pathways in dermatofibroma and dermatofibrosarcoma protuberans

• DOI: 10.2152/jmi.60.106
• 发表时间: 2013-02-01
• 期刊: JOURNAL OF MEDICAL INVESTIGATION
• 影响因子: 0.7
• 作者: Ishigami, Takeshi;Hida, Yasutoshi;Kubo, Yoshiaki
• 通讯作者: Kubo, Yoshiaki