Epigenetics abnormalities andescape fromthe immune system in epidermal keratinocytes
Epigenetics abnormalities andescape fromthe immune system in epidermal keratinocytes
批准号:
22591224
负责人:
KUBO Yoshiaki
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We examined the expression of all fibroblast growth factor receptors (FGFR1-4), their ligands (FGF1, 2, 9), and forkhead box N1 (FOXN1) in dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) by immunohistochemical analysis. Overexpression of FGFR3 and FOXN1 was observed in the epidermalregions of DF, and overexpression of FGF2 and FGFR4 was observed in the tumor lesions of DF. These expression patterns were in contrast with those of DFSP. We suppose tumor cells of DF may produce epigenetic changes in the epidermal regions of DF.
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会议论文
DOI:
10.2152/jmi.60.106
发表时间:
2013-02-01
期刊:
JOURNAL OF MEDICAL INVESTIGATION
影响因子:
0.7
作者:
[Ishigami, Takeshi, Hida, Yasutoshi, Kubo, Yoshiaki]
通讯作者:
Kubo, Yoshiaki
Reprogramming of epidermal keratinocytes and the process of tumorigenesis
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批准号:16K10159
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2016
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负责人:KUBO Yoshiaki
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依托单位:
Genomic instabilities and tumorigenesis in epidermal keratinocytes
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批准号:25461696
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2013
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负责人:KUBO Yoshiaki
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依托单位:
The regulation and abnormalities of the epigenetics on epidermal keratinocytes
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批准号:19591309
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2007
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负责人:KUBO Yoshiaki
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依托单位:
Molecular abnormalities of cell cycle regulations in epidermal keratinocytes for the clinical applications
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批准号:17591173
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2005
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负责人:KUBO Yoshiaki
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依托单位:
The research for the classification by molecular biology and the development of a novel therapy in squamous cell carcinomas of the skin
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批准号:15591180
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:2003
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负责人:KUBO Yoshiaki
-
依托单位:
The multistep process in skin carcinogenesis
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批准号:13670888
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:2001
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负责人:KUBO Yoshiaki
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依托单位:
海外基金