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Epigenetics abnormalities andescape fromthe immune system in epidermal keratinocytes

Epigenetics abnormalities andescape fromthe immune system in epidermal keratinocytes
表皮角质形成细胞的表观遗传学异常和免疫系统逃避
批准号:
22591224
负责人:
KUBO Yoshiaki
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We examined the expression of all fibroblast growth factor receptors (FGFR1-4), their ligands (FGF1, 2, 9), and forkhead box N1 (FOXN1) in dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) by immunohistochemical analysis. Overexpression of FGFR3 and FOXN1 was observed in the epidermalregions of DF, and overexpression of FGF2 and FGFR4 was observed in the tumor lesions of DF. These expression patterns were in contrast with those of DFSP. We suppose tumor cells of DF may produce epigenetic changes in the epidermal regions of DF.
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DOI: 10.2152/jmi.60.106
发表时间: 2013-02-01
期刊: JOURNAL OF MEDICAL INVESTIGATION
影响因子: 0.7
作者: [Ishigami, Takeshi, Hida, Yasutoshi, Kubo, Yoshiaki]
通讯作者: Kubo, Yoshiaki
Reprogramming of epidermal keratinocytes and the process of tumorigenesis
  • 批准号:
    16K10159
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.0万
  • 财政年份:
    2016
  • 负责人:
    KUBO Yoshiaki
  • 依托单位:
Genomic instabilities and tumorigenesis in epidermal keratinocytes
  • 批准号:
    25461696
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.16万
  • 财政年份:
    2013
  • 负责人:
    KUBO Yoshiaki
  • 依托单位:
The regulation and abnormalities of the epigenetics on epidermal keratinocytes
  • 批准号:
    19591309
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.75万
  • 财政年份:
    2007
  • 负责人:
    KUBO Yoshiaki
  • 依托单位:
Molecular abnormalities of cell cycle regulations in epidermal keratinocytes for the clinical applications
  • 批准号:
    17591173
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.18万
  • 财政年份:
    2005
  • 负责人:
    KUBO Yoshiaki
  • 依托单位:
海外基金