The establishment of gadolinium-induced skin fibrosis and calcification mice model.

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Nephrogenic systemic fibrosis (NSF) is an acquired disorder characterized by systemic fibrosis and abnormal calcification in patients with severe renal dysfunction. Growing evidence supports the hypothesis that gadolinium (Gd)-containing contrast agents used for magnetic resonance imaging trigger the development of NSF. The aim of this study was to establish the Gd-induced skin fibrosis and calcification mice model. Subcutaneous injection of bone marrow-derived mesenchymal stem cells and Gd-loaded hydorogel induced skin fibrosis in mice, but not skin calcification. Next we will examine the mechanism of Gd-induced skin fibrosis.