The establishment of gadolinium-induced skin fibrosis and calcification mice model.

钆诱导小鼠皮肤纤维化和钙化模型的建立。

• 批准号: 22591237
• 负责人: ISHIKAWA Osamu
• 金额: $ 2万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591237/
• 关键词: 腎性全身性線維症; ガドリニウム; 線維化; 石灰化; 間葉系幹細胞; 皮膚線維化; 皮膚石灰化; モデルマウス

Nephrogenic systemic fibrosis (NSF) is an acquired disorder characterized by systemic fibrosis and abnormal calcification in patients with severe renal dysfunction. Growing evidence supports the hypothesis that gadolinium (Gd)-containing contrast agents used for magnetic resonance imaging trigger the development of NSF. The aim of this study was to establish the Gd-induced skin fibrosis and calcification mice model. Subcutaneous injection of bone marrow-derived mesenchymal stem cells and Gd-loaded hydorogel induced skin fibrosis in mice, but not skin calcification. Next we will examine the mechanism of Gd-induced skin fibrosis.

肾源性系统性纤维化（NSF）是一种获得性疾病，其特征是严重肾功能不全患者的系统性纤维化和异常钙化。越来越多的证据支持这一假设，即用于磁共振成像的含钆（Gd）造影剂触发NSF的发展。本研究旨在建立Gd诱导的小鼠皮肤纤维化和钙化模型。皮下注射骨髓间充质干细胞和载钆水凝胶诱导小鼠皮肤纤维化，但不诱导皮肤钙化。接下来，我们将研究Gd诱导皮肤纤维化的机制。