Creation of atopic dermatitis model mouse using double knock out mouse

特应性皮炎是一种难治性皮肤病。该病的临床特征是瘙痒性湿疹。这种疾病现在是由微丝蛋白基因突变引起的。Loricrin是表皮角质细胞边缘带的主要成分。变异型Vohwinkel综合征的临床表现是伴有鱼鳞病的肢残性角化皮肤病。这种表型类似于寻常型鱼鳞病。寻常型鱼鳞病是由微丝蛋白基因的纯合或复合杂合突变引起的。本项目的目的是利用氯丙菊酯基因敲除小鼠建立特应性皮炎小鼠模型。

Atopic dermatitis is one of intractable skin diseases. The clinical feature of this disease is itchy eczema. This disease is caused by mutations in filaggrin gene now. Loricrin is major constituent of marginal band of epidermal corneocyte. The clinical aspects of the variant form of Vohwinkel syndrome are mutilating keratoderma with ichthyosis. This phenotype is similar to ichthyosis vulgaris. Ichthyosis vulgaris is caused by homozygous or compound heterozygous mutations in the filaggrin gene. The aim of this project is creation of atopic dermatitis mouse model using loricrin knock out mouse.