Development of living skin equivalent models over-expressing IL-22R on epidermal keratinocytes

IL-22是银屑病发病过程中必不可少的细胞因子。我们发现白介素22受体在银屑病的表皮角质形成细胞中表达增加。在这项研究中，我们阐明了干扰素-α增强培养的角质形成细胞IL-22R的表达，并且IL-22诱导的基因表达被IL-22上调的核Bcl3所增强，特别是当IL-22R过度表达时。这些发现表明，表皮角质形成细胞高表达IL-22R的活体皮肤等效模型可能也是研究银屑病发病机制的有用工具。

IL-22 is an essential cytokine in the pathogenesis of psoriasis. We have found that IL-22 receptor expression is increased in the epidermal keratinocytes of psoriasis. In this study, we elucidated that IFN-αenhances IL-22R expression in cultured keratinocytes, and that IL-22-inducible gene expression is enhanced by nuclear Bcl-3 which is increased by IL-22, particular when IL-22R is over-expressed. These findings suggest that living skin equivalent models highly-expressing IL-22R on epidermal keratinocytes may be a useful too for studying the pathogenesis of psoriasis.