Neuroimaging studies on cognitive function in schizophrenia

我们进行了一系列的研究，以探讨精神分裂症认知功能障碍的病理生理基础。在非线性EEG分析中，患者在额颞区的更高时间尺度上表现出比健康对照更高的复杂性。其次，我们研究了杏仁核的反应，在面部识别使用功能磁共振成像;精神分裂症患者表现出更突出的激活右侧杏仁核比对照组。相比之下，高功能自闭症谱系障碍的个体在面部识别任务中表现出比对照组更少的杏仁核活动。最后，我们评估了5-羟色胺-1A部分激动剂坦度螺酮的作用，并通过剑桥神经心理测试自动组合检测发现患者的额叶认知功能障碍得到改善。

We performed a series of studies to explore the pathophysiology underlying cognitive dysfunction in schizophrenia. In a non-linear EEG analysis, patients showed higher complexity at higher time scales than healthy controls over the fronto-temporal regions. Secondly, we investigated amygdala responses during facial recognition using a functional magnetic resonance imaging; Schizophrenia patients showed more prominent activation of the right amygdala than controls. In contrast, individuals with high-functioning autism spectrum disorders showed less amygdala activity than controls during facial recognition task. Finally, we assessed the effects of tandospirone, a serotonin-1A partial agonist, and found the improvement of frontal cognitive dysfunction of patients detected by Cambridge Neuropsychological Test Automated Battery.