Neuroimaging studies on cognitive function in schizophrenia

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We performed a series of studies to explore the pathophysiology underlying cognitive dysfunction in schizophrenia. In a non-linear EEG analysis, patients showed higher complexity at higher time scales than healthy controls over the fronto-temporal regions. Secondly, we investigated amygdala responses during facial recognition using a functional magnetic resonance imaging; Schizophrenia patients showed more prominent activation of the right amygdala than controls. In contrast, individuals with high-functioning autism spectrum disorders showed less amygdala activity than controls during facial recognition task. Finally, we assessed the effects of tandospirone, a serotonin-1A partial agonist, and found the improvement of frontal cognitive dysfunction of patients detected by Cambridge Neuropsychological Test Automated Battery.