Early prediction of therapeutic effect of molecular targeting therapy for solid malignant tumor with imaging biomarkers

影像学标志物早期预测实体恶性肿瘤分子靶向治疗疗效

• 批准号: 22591319
• 负责人: KOBAYASHI Satoshi
• 金额: $ 1.66万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591319/
• 关键词: 肝細胞癌; 分子標的治療; 造影CT; Dual-Energy CT; ヨードマップ

Dilatation of intratumoral vessels on multiphasic contrast enhanced CT was estimated to be one of the key findings for prediction of early therapeutic effect evaluation of molecular-targeting therapy for hepatocellular carcinoma (HCC). There are no significant correlation between hemodynamic parameters of CT perfusion just after starting of molecular-targeting therapy for HCC and long term therapeutic effect of it. In contrast, intratumoral iodine measurement obtained by dual-energy CT technique might be used as surrogate marker for early prediction of therapeutic effect of molecular targeting therapy for HCC.

多期增强CT显示肿瘤内血管扩张是预测肝癌分子靶向治疗早期疗效的关键指标之一。肝癌分子靶向治疗后即刻CT灌注血流动力学参数与远期疗效无明显相关性，而双能CT测量肿瘤内碘含量可作为早期预测肝癌分子靶向治疗疗效的替代指标。

项目成果

Image Based Analysis of Reduction Effect On Multicentric Type Recurrence of Hepatocellular Carcinoma With Peretinoin”

基于图像的Peretinoin减少肝细胞癌多中心型复发的效果分析》

• 发表时间: 2012
• 作者: Kobayashi S;et al
• 通讯作者: et al

Gd-EOB-DTPA造影MRIによる肝腫瘍画像診断

Gd-EOB-DTPA增强MRI肝脏肿瘤影像诊断

• 发表时间: 2010
• 期刊: Rad Fan
• 作者: 小林聡;ほか
• 通讯作者: ほか

Initial experience of Dual source Dual energy CT for hepatic imaging: Impact of Iodine Map on hemodynamic analysis of the liver lesion

双源双能CT肝脏成像初体验：碘图对肝脏病灶血流动力学分析的影响

• 发表时间: 2011
• 作者: Kobayashi S;Matsui O;Gabata T;Koda W;Minami T;Ryu Y;Kawai K;Kozaka K
• 通讯作者: Kozaka K

Radiologic manifestation of hepatic pseudolesions and pseudotumors in the third inflow area

第三流入区肝脏假性病变和假性肿瘤的影像学表现

• 发表时间: 2011
• 作者: Kobayashi S;et al
• 通讯作者: et al

Initial experience of Dual source Dual energy CT for hepatic imaging : Impactof Iodine Map on hemodynamic analysis of the liver lesion.

双源双能CT肝脏成像初步经验：碘图对肝脏病变血流动力学分析的影响。

• 发表时间: 2011
• 作者: Kobayashi S;et al.
• 通讯作者: et al.