Development of material design for bio-absorbable composites toward tailor made medical treatments

开发生物可吸收复合材料的材料设计以实现定制医疗

• 批准号: 22686014
• 负责人: KOBAYASHI Satoshi
• 金额: $ 16.47万
• 依托单位: Tokyo Metropolitan University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22686014/
• 关键词: 生体吸収性プラスチック; ポリL乳酸; 生体吸収性複合材料; 高次構造; 結晶化; 配向; マイクロメカニックス; 損傷力学

In order to realize a tailor-made medical treatment considering region and degree of disease, mechanical and hydrolysis properties for poly(L-lactic acid)/ tri-calcium phosphate composites were investigated experimentally and analytically as a function of the content of tri-calcium phosphate. Mechanical behavior was predicted based upon modified micromechanics. Molecular weight distributions, as hydrolysis behavior, were analytically predicted considering self-catalytic effect of carboxyl group. Since it is confirmed that variations in mechanical behavior associated with hydrolysis is caused by degradation around interphase between tri-calcium phosphate/ poly(L-lactic acid), mechanical behavior was predicted considering interfacial debonding with hydrolysis. In addition, mechanical properties of the composites were improved with an interfacial treatments.

为了实现针对不同地区和不同疾病程度的个性化医疗，对聚L-乳酸/磷酸三钙复合材料的力学性能和水解性能进行了实验研究，并分析了磷酸三钙含量对复合材料力学性能和水解性能的影响。基于修正的细观力学理论预测了其力学行为。考虑到羧基的自催化作用，对水解行为中的分子量分布进行了解析预测。由于已证实与水解相关的机械行为变化是由磷酸三钙/聚（L-乳酸）之间界面周围的降解引起的，因此考虑到水解的界面脱粘，预测了机械行为。此外，通过界面处理，提高了复合材料的力学性能。

项目成果

生体吸収性複合材料の破壊挙動に及ぼすリン酸緩衝液浸漬の影響

磷酸盐缓冲液浸泡对生物可吸收复合材料断裂行为的影响

• 发表时间: 2012
• 作者: T.Taishi;Y.Hashimoto;H.Ise;Y.Murao;T.Ohsawa;Y.Tokumoto;Y.Ohno;I.Yonenaga;松谷浩二朗
• 通讯作者: 松谷浩二朗

Effect of Interfacial Treatment using L-Lactic Acid On Mechanical Properties of β-TCP/PLLA Composites

L-乳酸界面处理对β-TCP/PLLA复合材料力学性能的影响

• 发表时间: 2011
• 作者: Risa NAGAO;Satoshi KOBAYASHI
• 通讯作者: Satoshi KOBAYASHI

Analytical prediction of hydrolysis behavior of tricalcium phosphate/ poly-L-lactic acid composites in simulated body environment

磷酸三钙/聚L-乳酸复合材料在模拟人体环境中水解行为的分析预测

• DOI: 10.1080/09243046.2013.844902
• 发表时间: 2014
• 期刊: Advanced Composite Materials
• 影响因子: 2.9
• 作者: T.Ochiai;N.Takeuchi;S.Yoshida;O.Takeuchi;H.Shigekawa;Satoshi KOBAYASHI and Shusaku Yamaji
• 通讯作者: Satoshi KOBAYASHI and Shusaku Yamaji

Effect of in vitro hydrolysis on the compressive behavior and strain rates dependence of tricalcium phosphate/poly(L-lactic acid) composites

体外水解对磷酸三钙/聚（L-乳酸）复合材料压缩行为和应变率依赖性的影响

• DOI: 10.1080/09243046.2012.760437
• 发表时间: 2013
• 期刊: Advanced Composite Materials
• 影响因子: 2.9
• 作者: Shusaku Yamaji;Satoshi Kobayashi
• 通讯作者: Satoshi Kobayashi

β 型リン酸三カルシウム/ポリL 乳酸複合材料の微視的破壊挙動に及ぼす界面処理の影響

界面处理对β型磷酸三钙/聚L-乳酸复合材料微观断裂行为的影响

• 发表时间: 2011
• 作者: 長尾梨紗;小林訓史
• 通讯作者: 小林訓史