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Development of material design for bio-absorbable composites toward tailor made medical treatments

Development of material design for bio-absorbable composites toward tailor made medical treatments
开发生物可吸收复合材料的材料设计以实现定制医疗
批准号：
22686014
负责人：
KOBAYASHI Satoshi
金额：
$16.47万
依托单位：
Tokyo Metropolitan University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (A)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22686014/
关键词：
生体吸収性プラスチックポリL乳酸生体吸収性複合材料高次構造結晶化配向マイクロメカニックス損傷力学

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中文摘要
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英文摘要
In order to realize a tailor-made medical treatment considering region and degree of disease, mechanical and hydrolysis properties for poly(L-lactic acid)/ tri-calcium phosphate composites were investigated experimentally and analytically as a function of the content of tri-calcium phosphate. Mechanical behavior was predicted based upon modified micromechanics. Molecular weight distributions, as hydrolysis behavior, were analytically predicted considering self-catalytic effect of carboxyl group. Since it is confirmed that variations in mechanical behavior associated with hydrolysis is caused by degradation around interphase between tri-calcium phosphate/ poly(L-lactic acid), mechanical behavior was predicted considering interfacial debonding with hydrolysis. In addition, mechanical properties of the composites were improved with an interfacial treatments.
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会议论文
生体吸収性複合材料の破壊挙動に及ぼすリン酸緩衝液浸漬の影響
磷酸盐缓冲液浸泡对生物可吸收复合材料断裂行为的影响
DOI： --
发表时间： 2012
期刊：
影响因子： --
作者： [T.Taishi, Y.Hashimoto, H.Ise, Y.Murao, T.Ohsawa, Y.Tokumoto, Y.Ohno, I.Yonenaga, 松谷浩二朗]
通讯作者： 松谷浩二朗
Analytical prediction of hydrolysis behavior of tricalcium phosphate/ poly-L-lactic acid composites in simulated body environment
磷酸三钙/聚L-乳酸复合材料在模拟人体环境中水解行为的分析预测
DOI： 10.1080/09243046.2013.844902
发表时间： 2014
期刊： Advanced Composite Materials
影响因子： 2.9
作者： [T.Ochiai, N.Takeuchi, S.Yoshida, O.Takeuchi, H.Shigekawa, Satoshi KOBAYASHI and Shusaku Yamaji]
通讯作者： Satoshi KOBAYASHI and Shusaku Yamaji
Effect of Interfacial Treatment using L-Lactic Acid On Mechanical Properties of β-TCP/PLLA Composites
L-乳酸界面处理对β-TCP/PLLA复合材料力学性能的影响
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Risa NAGAO, Satoshi KOBAYASHI]
通讯作者： Satoshi KOBAYASHI
Effect of in vitro hydrolysis on the compressive behavior and strain rates dependence of tricalcium phosphate/poly(L-lactic acid) composites
体外水解对磷酸三钙/聚（L-乳酸）复合材料压缩行为和应变率依赖性的影响
DOI： 10.1080/09243046.2012.760437
发表时间： 2013
期刊： Advanced Composite Materials
影响因子： 2.9
作者： [Shusaku Yamaji, Satoshi Kobayashi]
通讯作者： Satoshi Kobayashi
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