Development of material design for bio-absorbable composites toward tailor made medical treatments

为了实现针对不同地区和不同疾病程度的个性化医疗，对聚L-乳酸/磷酸三钙复合材料的力学性能和水解性能进行了实验研究，并分析了磷酸三钙含量对复合材料力学性能和水解性能的影响。基于修正的细观力学理论预测了其力学行为。考虑到羧基的自催化作用，对水解行为中的分子量分布进行了解析预测。由于已证实与水解相关的机械行为变化是由磷酸三钙/聚（L-乳酸）之间界面周围的降解引起的，因此考虑到水解的界面脱粘，预测了机械行为。此外，通过界面处理，提高了复合材料的力学性能。

In order to realize a tailor-made medical treatment considering region and degree of disease, mechanical and hydrolysis properties for poly(L-lactic acid)/ tri-calcium phosphate composites were investigated experimentally and analytically as a function of the content of tri-calcium phosphate. Mechanical behavior was predicted based upon modified micromechanics. Molecular weight distributions, as hydrolysis behavior, were analytically predicted considering self-catalytic effect of carboxyl group. Since it is confirmed that variations in mechanical behavior associated with hydrolysis is caused by degradation around interphase between tri-calcium phosphate/ poly(L-lactic acid), mechanical behavior was predicted considering interfacial debonding with hydrolysis. In addition, mechanical properties of the composites were improved with an interfacial treatments.