Development of multi-parametric MRI for preclinical diagnosis of Alzheimer's disease
Development of multi-parametric MRI for preclinical diagnosis of Alzheimer's disease
批准号:
22591340
负责人:
YOSHIURA Takashi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We revealed early morphological changes in gray and white matter in mild cognitiveimpairment using voxel-based morphometry (VBM). We developed a novel multi-parametric method by combining VBM and ASL, and showed that our method is superior to each method alone in diagnosing AD. In addition, we developed a high-resolution diffusion tensor imaging method to detect early AD pathology in the hippocampus.
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Automated measurement of three-dimensional cerebral cortical thickness in Alzheimer's patients using localized gradient vector trajectory in fuzzy membership maps
使用模糊隶属图中的局部梯度矢量轨迹自动测量阿尔茨海默病患者的三维大脑皮层厚度
DOI:
--
发表时间:
2013
期刊:
J Biomed Sci Eng
影响因子:
--
作者:
[Tokunaga C, Arimura H, Ohara T, Yamashita Y, Kobayashi K, Magome T, Nakamura Y, Honda H, Hirata H, Ohki M, Toyofuku H]
通讯作者:
Toyofuku H
MR imaging of Alzheimer's disease
阿尔茨海默病的磁共振成像
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kumazawa S, Yoshiura T, et al, Yoshiura T]
通讯作者:
Yoshiura T
DOI:
10.1258/ar.2012.120450
发表时间:
2013-02-01
期刊:
ACTA RADIOLOGICA
影响因子:
1.3
作者:
[Kamano, Hironori, Yoshiura, Takashi, Honda, Hiroshi]
通讯作者:
Honda, Hiroshi
DWI とASL を中心とした頭部機能 MRI 診断の臨床的有用性
以DWI和ASL为中心的头功能MRI诊断的临床应用
DOI:
--
发表时间:
2011
期刊:
INNERVISION
影响因子:
--
作者:
[樋渡 昭雄, 吉浦 敬, 栂尾 理, 山下孝二, 菊地 一史, 本田 浩]
通讯作者:
本田 浩
In-vivo detection of intracortical myelinated fibers in hippocampal formation: submillimeter resolution diffusion tensor imaging compared with histological findings
海马结构中皮质内有髓纤维的体内检测:亚毫米分辨率扩散张量成像与组织学结果的比较
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[徳永千晶, 有村秀孝, 吉浦 敬, Yoshiura T et al]
通讯作者:
Yoshiura T et al
共 34 条
Development of MR molecular imaging for brain amyloid detection: PET/MRI approach
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批准号:26670564
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2014
-
负责人:YOSHIURA Takashi
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依托单位:
Brain network imaging based on diffusion tensor MRI : Technical development and clinical applications
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批准号:18591351
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.49万
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财政年份:2006
-
负责人:YOSHIURA Takashi
-
依托单位:
海外基金