Development of Functional Image-Guided Radiotherapy Planning inIntensity-Modulated Radiation Therapy (IMRT) for Lung Cancer

我们对8名肺癌患者进行了模拟研究，并得出结论，基于IMRT或IMAT中的低衰减区（LAA）的功能图像引导放疗计划似乎可以有效地保留肺癌合并慢性阻塞性肺疾病（COPD）患者的功能肺。之后，广岛大学医院审查委员会批准了本研究，我们收集了接受放疗的肺癌患者的4D-CT、肺灌注图像、肺功能的数据，以确定最佳的功能影像学。

We performed a simulation study in eight lung cancer patients, and concluded functional image-guided radiotherapy planning based on low attenuation area (LAA) in IMRT or IMAT appeared to be effective in preserving a functional lung in lung cancer patients with chronic obstructive pulmonary disease (COPD). After that, Hiroshima University Hospital Review Board approved this study, and we collected data of 4D-CT, pulmonary perfusion image, pulmonary function of lung cancer patients who received radiotherapy to determine optimal functional imaging.