Development of a novel sentinel lymph node biopsy method using fluorescent nano-particles

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We succeeded in real-time fluorescent imaging of sentinel lymph nodes of various gastrointestinal tracts in pig model using QDs as a tracer. After that, we analyzed fluorescent specificities in varied conditions and revealed the range of a signal detection through fat tissue or other organs. Furthermore, we developed novel organic material nanoparticles as a safety fluorescent probe for sentinel lymph node biopsy(SLNB) with the idea of clinical application. We revealed that these particles were suitable for SLNB and their fluorescent specificities were similar to the QDs.