Development of a novel sentinel lymph node biopsy method using fluorescent nano-particles

利用量子点作为示踪剂，成功地对猪模型中不同胃肠道前哨淋巴结进行了实时荧光成像。之后，我们分析了不同条件下的荧光特性，并揭示了通过脂肪组织或其他器官检测到信号的范围。此外，我们还开发了一种新型有机材料纳米颗粒作为前哨淋巴结活检(SLNB)的安全荧光探针，以期用于临床应用。我们发现这些颗粒适合于SLNB，它们的荧光特性与量子点相似。

We succeeded in real-time fluorescent imaging of sentinel lymph nodes of various gastrointestinal tracts in pig model using QDs as a tracer. After that, we analyzed fluorescent specificities in varied conditions and revealed the range of a signal detection through fat tissue or other organs. Furthermore, we developed novel organic material nanoparticles as a safety fluorescent probe for sentinel lymph node biopsy(SLNB) with the idea of clinical application. We revealed that these particles were suitable for SLNB and their fluorescent specificities were similar to the QDs.