Reversible photo-regulation of the motor functions of kinesin by a novel photochromic ATP analog
Reversible photo-regulation of the motor functions of kinesin by a novel photochromic ATP analog
批准号:
24770140
负责人:
KAMEI Takashi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
We obtained the following two main results in this research.(1) We synthesized novel adenosine triphosphate (ATP) analogs, ATP-Azos, which were chimeric molecules of ATP and azobenzene compounds exhibiting a reversible and large conformational change by photo-irradiations. In aqueous solutions, photo-responsive properties of the ATP-Azos were revealed with spectroscopic methods.(2) In the presence of an ATP-Azo, we assessed the motile properties of kinesin, a bio-molecular motor, which derives the mechanical energy from ATP hydrolysis, with or without photo-irradiations. Consequently, we realized reversible photo-modulation of motility of kinesin by irradiations.
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フォトクロミック化合物を用いたキネシン―微小管系の運動の可逆的光制御
使用光致变色化合物对驱动蛋白-微管系统运动进行可逆光学控制
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[亀井敬, Nishad Perur, Kumar Sunil, 深港豪, 玉置信之]
通讯作者:
玉置信之
A non-nucleoside triphosphate for powering kinesin-microtubule motility with photo-tunable velocity.
一种非核苷三磷酸,用于以光可调速度为驱动蛋白微管运动提供动力。
DOI:
--
发表时间:
2013
期刊:
Chemical Communications
影响因子:
4.9
作者:
[Nishad Perur, Masao Yahara, T. Kamei, N. Tamaoki]
通讯作者:
N. Tamaoki
フォトクロミック化合物を用いたキネシン-微小管系の運動の可逆的光制御
使用光致变色化合物对驱动蛋白-微管系统运动进行可逆光学控制
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[亀井敬, Nishad Perur, Kumar Sunil, 深港豪, 玉置信之]
通讯作者:
玉置信之
A Photochromic ATP Analogue Driving a Motor Protein with Reversibly Light-Controlled Motility
光致变色 ATP 类似物驱动具有可逆光控运动的运动蛋白
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[亀井敬, 深港豪, 玉置信之]
通讯作者:
玉置信之
Reversible control of F1-ATPase rotational motion using a photochromic ATP analog at the single moecule level
使用光致变色 ATP 类似物在单分子水平可逆控制 F1-ATPase 旋转运动
DOI:
10.1016/j.bbrc.2014.02.117
发表时间:
2014
期刊:
Biochem. Biophys. Res. Commun.
影响因子:
--
作者:
[Sunamura, E., Kamei, K., Konno, H., Tamaoki, N., Hisabori, T.]
通讯作者:
T.
共 15 条
Development of a novel sentinel lymph node biopsy method using fluorescent nano-particles
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批准号:22591396
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2010
-
负责人:KAMEI Takashi
-
依托单位:
Study of feasibility and optimization of energy system from a view of SCM
-
批准号:21710152
-
项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
-
财政年份:2009
-
负责人:KAMEI Takashi
-
依托单位:
In vivo real time imaging of esophageal cancer with CdSe nanoparticle
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批准号:19591527
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
-
财政年份:2007
-
负责人:KAMEI Takashi
-
依托单位:
海外基金